INT269904

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox17) DNA binding (Sox17) transcription factor binding (Sox17)
Anatomy Link Frequency
respiratory 2
Sox17 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Hypoglycemia 2 5.00 Very Low Very Low Very Low
Colon Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results demonstrate that Sox17 expression in adult mouse lung results in decreased levels of cyclin-dependent kinase inhibitors associated with G1 arrest and increased expression of cell cycle-promoting genes, providing insight into the molecular mechanisms that regulate Sox17-induced proliferation associated with the initiation of progenitor cell behavior in respiratory epithelial cells.


Regulation (regulate) of Sox17 in respiratory
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Since cyclin D1 is a key regulator of progression through the G1 phase of the cell cycle and was increased in lungs from CCSPrtTA/tetO-Sox17 mice, we sought to determine if it was a direct downstream target of Sox17 during induction of respiratory epithelial cell proliferation.
Regulation (target) of Sox17 in respiratory
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

General Comments

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