INT269919

Context Info Confidence 0.36 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

DNA binding (Sox17, Smad3) nucleus (Sox17, Smad3) transcription factor binding (Sox17, Smad3) transport (Smad3) intracellular (Smad3) protein complex (Smad3)

Sox17 (Mus musculus) Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Repression 7 5.00 Targeted Disruption 4 5.00 Hyperplasia 2 5.00 Injury 2 5.00 Exsanguination 1 5.00 Apoptosis 1 5.00 Breast Cancer 1 5.00 Cancer 1 5.00 Hypoglycemia 1 5.00 Colon Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further, Sox17 interacted with Smad3 and blocked Smad3 DNA binding and transcriptional activity.

Sox17 Negative_regulation (blocked) of Smad3 Binding (binding) of

1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

General Comments

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