INT269940

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn4a) nucleus (Sox17) DNA binding (Sox17)
transcription factor binding (Sox17) transmembrane transport (Scn4a)
Anatomy Link Frequency
MH1 2
Sox17 (Mus musculus)
Scn4a (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 80.92 Quite High
Hypoglycemia 2 21.56 Low Low
Colon Cancer 2 12.04 Low Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although both the MH1 and MH2 domains of Smad3 bound Sox17, the strongest interaction was localized to the linker region and MH2 domains.
Sox17 Binding (bound) of MH2 in MH1
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.15 Pain Relevance 0
While both the MAD homology domains (MH1 and MH2) of Smad3 interacted with Sox17 at low stringency binding conditions (data not shown), Smad3 1–145 did not bind to Sox17 under higher stringency conditions (Fig. 7B).
Sox17 Binding (interacted) of MH2 in MH1
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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