INT269942

Context Info Confidence 0.37 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.12 Pain Relevance 0

DNA binding (Sox17, Smad3) nucleus (Sox17, Smad3) transcription factor binding (Sox17, Smad3) transport (Smad3) intracellular (Smad3) protein complex (Smad3)

Sox17 (Mus musculus) Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Repression 7 66.16 Hypoglycemia 1 6.80 Targeted Disruption 4 5.00 Hyperplasia 2 5.00 Injury 2 5.00 Exsanguination 1 5.00 Apoptosis 1 5.00 Breast Cancer 1 5.00 Cancer 1 5.00 Colon Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, Sox17 interaction with these domains is consistent with the antagonistic effects of Sox17 on Smad3 DNA binding and transcriptional activity.

Sox17 Regulation (effects) of Smad3

1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.