INT269948

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox17, Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
DNA binding (Sox17) cytoplasm (Ccnd1) cell cycle (Ccnd1)
Sox17 (Mus musculus)
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 21 96.84 Very High Very High Very High
Hypoglycemia 3 45.08 Quite Low
Colon Cancer 3 35.56 Quite Low
Breast Cancer 3 26.52 Quite Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Exsanguination 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sox17 induces cyclin D1 expression
Sox17 Positive_regulation (induces) of Gene_expression (expression) of cyclin D1
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Notably, Sox17 enhanced cyclin D1 expression in vivo and activated cyclin D1 promoter activity in vitro.
Sox17 Positive_regulation (enhanced) of Gene_expression (expression) of cyclin D1
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
While we favor the notion that Sox17 directly activates the cyclin D1 promoter, it is possible that inhibiting TGF-?
Sox17 Positive_regulation (activates) of Gene_expression (directly) of cyclin D1
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.19 Pain Relevance 0

General Comments

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