INT269949

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox17, Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
DNA binding (Sox17) cytoplasm (Ccnd1) cell cycle (Ccnd1)
Anatomy Link Frequency
epithelial cells 2
respiratory 1
Sox17 (Mus musculus)
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 49 96.84 Very High Very High Very High
Hypoglycemia 7 87.20 High High
Injury 14 78.32 Quite High
Colon Cancer 7 77.68 Quite High
Breast Cancer 7 72.40 Quite High
Targeted Disruption 28 55.28 Quite High
Hyperplasia 14 5.00 Very Low Very Low Very Low
Exsanguination 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the induction of cyclin D1 by Sox17 is likely to play an important role in stimulating mature respiratory epithelial cells to reenter the cell cycle.
Sox17 Positive_regulation (induction) of cyclin D1 in respiratory
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
While we favor the notion that Sox17 directly activates the cyclin D1 promoter, it is possible that inhibiting TGF-?
Sox17 Positive_regulation (activates) of cyclin D1
2) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.19 Pain Relevance 0
Although it is unclear whether Sox17 is a transcriptional activator of cyclin D1 in vivo, our data support a potential mechanism by which Sox17 directly induces cyclin D1 to promote proliferation of a subset of mature respiratory epithelial cells.
Sox17 Positive_regulation (induces) of cyclin D1 in epithelial cells
3) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.22 Pain Relevance 0
Our in vitro studies demonstrated that Sox17 directly activated the human cyclin D1 promoter through a conserved site located at ?
Sox17 Positive_regulation (activated) of cyclin D1
4) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.13 Pain Relevance 0
Although it is unclear whether Sox17 is a transcriptional activator of cyclin D1 in vivo, our data support a potential mechanism by which Sox17 directly induces cyclin D1 to promote proliferation of a subset of mature respiratory epithelial cells.
Sox17 Spec (whether) Positive_regulation (activator) of cyclin D1 in epithelial cells
5) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.23 Pain Relevance 0
Notably, Sox17 enhanced cyclin D1 expression in vivo and activated cyclin D1 promoter activity in vitro.
Sox17 Positive_regulation (activated) of cyclin D1
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Our data shows that the ability of Sox17 to induce progenitor cell behavior is mediated, at least in part, by activating cyclin D1 and decreasing TGF-?
Sox17 Positive_regulation (activating) of cyclin D1
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox