INT26996

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Context Info
Confidence 0.68
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 21.55
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp) extracellular region (Crp)
Anatomy Link Frequency
erythrocyte 8
plasma 2
coronary artery 2
Crp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 62 100.00 Very High Very High Very High
Inflammatory response 13 96.68 Very High Very High Very High
abdominal pain 4 96.60 Very High Very High Very High
abatacept 8 91.20 High High
Inflammatory marker 39 90.96 High High
aspirin 59 90.64 High High
alcohol 9 86.80 High High
depression 2 85.16 High High
cINOD 4 84.96 Quite High
cva 6 84.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 117 100.00 Very High Very High Very High
Carcinoma 2 100.00 Very High Very High Very High
Diabetes Mellitus 360 99.96 Very High Very High Very High
Anaemia 3 99.96 Very High Very High Very High
Myocardial Infarction 74 99.76 Very High Very High Very High
Injury 19 99.44 Very High Very High Very High
Coronary Artery Disease 30 99.20 Very High Very High Very High
Adhesions 7 99.12 Very High Very High Very High
Diabetic Cardiomyopathies 105 98.78 Very High Very High Very High
Insulin Resistance 50 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of C-reactive protein, erythrocyte sedimentation rate and procalcitonin were detected in 88%, 94% and 42% of the patients, respectively.
Positive_regulation (Increased) of Gene_expression (levels) of C-reactive protein in erythrocyte
1) Confidence 0.68 Published 2008 Journal Mikrobiyol Bul Section Abstract Doc Link 18697423 Disease Relevance 1.17 Pain Relevance 0.09
hsCRP – highly sensitive C-reactive protein
Positive_regulation (highly) of Gene_expression (sensitive) of CRP
2) Confidence 0.49 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 2.02 Pain Relevance 0
Levels of C-reactive protein or erythrocyte sedimentation rates were elevated in all cases, usually to levels found in serious bacterial diseases.
Positive_regulation (elevated) of Gene_expression (Levels) of C-reactive protein in erythrocyte associated with bacterial infection
3) Confidence 0.46 Published 1989 Journal Rev. Infect. Dis. Section Abstract Doc Link 2574903 Disease Relevance 1.93 Pain Relevance 0.32
Laboratory investigations showed an increase in C-reactive protein and carcinoma antigen 125 serum levels.
Positive_regulation (increase) of Gene_expression (levels) of C-reactive protein associated with carcinoma
4) Confidence 0.40 Published 2003 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 12678341 Disease Relevance 1.28 Pain Relevance 0.10
All patients had elevated procalcitonin and C-reactive protein levels within 24 hours of diagnosis.
Positive_regulation (elevated) of Gene_expression (levels) of C-reactive protein
5) Confidence 0.30 Published 2002 Journal Crit Care Section Body Doc Link PMC137313 Disease Relevance 0.25 Pain Relevance 0.03
Additionally, C-reactive protein reduces endothelial nitric oxide synthase, upregulates the proatherosclerotic NF-?
Positive_regulation (upregulates) of Gene_expression (reduces) of C-reactive protein
6) Confidence 0.28 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1160573 Disease Relevance 1.15 Pain Relevance 0.19
Insulin resistance is often associated with a combination of established and emerging risk factors, including hypertension and C-reactive protein.88,89 C-reactive protein is an acute-phase inflammation marker that has been associated with an increased risk for DCM.90,91 Recent studies have confirmed the association between increased levels of C-reactive protein and worse LV myocardial performance, as well as risk factors for atherosclerosis and cardiovascular disease in subjects with metabolic syndrome (MetS).92 MetS status per se was found to be the strongest predictor of cardiomyopathy, thus implying that the clustering of the metabolic disturbances has additional prognostic information than its individual components in terms of myocardial performance and may explain in part the excess cardiovascular risk present in the MetS.92
Positive_regulation (increased) of Gene_expression (levels) of C-reactive protein associated with cardiomyopathy, pressure and volume under development, atherosclerosis, metabolic syndrome, diabetic cardiomyopathies, insulin resistance, cardiovascular disorder under development and inflammation
7) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 2.01 Pain Relevance 0.09
The increase in the plasma levels of bactericidal permeability-increasing protein, lipopolysaccharide-binding protein, and C-reactive protein showed the same pattern in all groups, and no significant differences among the 4 groups were observed.
Positive_regulation (increase) of Gene_expression (levels) of C-reactive protein in plasma
8) Confidence 0.07 Published 2007 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 17678776 Disease Relevance 0.05 Pain Relevance 0
Laboratory findings indicated anemia, increased levels of C-reactive protein, and erythrocyte sedimentation rate.
Positive_regulation (increased) of Gene_expression (levels) of C-reactive protein in erythrocyte associated with anaemia
9) Confidence 0.07 Published 2008 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 18974626 Disease Relevance 1.13 Pain Relevance 0.13
Markers of high long-term risk are old age, prior history of myocardial infarction, diabetes, elevated levels of C-reactive protein, and the extent of coronary artery disease and left ventricular dysfunction.
Positive_regulation (elevated) of Gene_expression (levels) of C-reactive protein in coronary artery associated with coronary artery disease, left ventricular dysfunction, diabetes mellitus and myocardial infarction
10) Confidence 0.07 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11567670 Disease Relevance 1.34 Pain Relevance 0.16
The mean C-reactive protein and procalcitonin levels were significantly higher in septic patients than in patients with trauma.
Positive_regulation (mean) of Gene_expression (levels) of C-reactive protein associated with injury
11) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1269453 Disease Relevance 2.08 Pain Relevance 0.05
In patients with high serum cholesterol levels, the risk of coronary events rose with increasing levels of fibrinogen and C-reactive protein, but the risk remained low even given high serum cholesterol levels in the presence of low fibrinogen concentrations.
Positive_regulation (increasing) of Gene_expression (levels) of C-reactive protein
12) Confidence 0.06 Published 1995 Journal N. Engl. J. Med. Section Body Doc Link 7845427 Disease Relevance 0 Pain Relevance 0
From this point of view, several studies have documented that diabetes is associated with elevated levels of C-reactive protein [15] and endothelial adhesion molecules, considered as markers of the endothelial inflammatory response [16,17].
Positive_regulation (elevated) of Gene_expression (levels) of C-reactive protein associated with inflammatory response, diabetes mellitus and adhesions
13) Confidence 0.05 Published 2007 Journal Trials Section Body Doc Link PMC2014771 Disease Relevance 1.02 Pain Relevance 0.43
Levels of ferritin, uric acid, white cell counts, fibrinogen, and C-reactive protein were significantly higher in individuals with a higher HOMA of insulin resistance (HOMA-IR).
Positive_regulation (higher) of Gene_expression (Levels) of C-reactive protein associated with insulin resistance
14) Confidence 0.04 Published 2004 Journal Diabetes Care Section Abstract Doc Link 15562214 Disease Relevance 1.11 Pain Relevance 0.25
All sera were additionally studied for presence of antinuclear antibodies (ANAs), antihistone and anticardiolipin antibodies, cryoglobulins, complement factors C3 and C4, C-reactive protein and ?
Positive_regulation (studied) of Gene_expression (presence) of C-reactive protein
15) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257446 Disease Relevance 1.39 Pain Relevance 0.15
The IL-6 response was characterized by an indirect-response model, in which the IL-6 production rate increased with baseline C-reactive protein levels.
Positive_regulation (increased) of Gene_expression (levels) of C-reactive protein
16) Confidence 0.03 Published 2007 Journal J Clin Pharmacol Section Abstract Doc Link 17962428 Disease Relevance 0.64 Pain Relevance 0.67
On the vascular side, high levels of UA are linked to cardiovascular diseases, especially HT.82–86 If patients are already at risk, then UA represents a serious problem.87,88 Mechanisms that are responsible for the deleterious UA effects are linked to increased C reactive protein, inflammation and reduced NO production, thereby hampering vascular reactivity.38,82,84,89
Neg (NO) Positive_regulation (increased) of Neg (NO) Gene_expression (production) of reactive protein associated with inflammation, cardiovascular disease and hypertension
17) Confidence 0.03 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 1.00 Pain Relevance 0.05
Erythrocyte sedimentation rate and C-reactive protein levels can indicate the extent of systemic inflammation, and cytoplasmic-staining antineutrophil cytoplasmic antibodies (such as to proteinase 3) are useful markers for vasculitides such as Wegener’s granulomatosis.28
Positive_regulation (indicate) of Gene_expression (levels) of C-reactive protein in Erythrocyte associated with inflammation and vasculitis
18) Confidence 0.03 Published 2010 Journal International Journal of General Medicine Section Body Doc Link PMC2866556 Disease Relevance 0.58 Pain Relevance 0.05
RESULTS: The following cut-off values for prediction of cardiac events were calculated: troponin I at baseline 0.3 ng/ml (predictive accuracy=0.870), troponin I at 6 h 0.50 ng/ml (p.a.=0.909); troponin T at baseline 0.05 ng/ml (p.a.=0.643), troponin T at 6 h 0.05 ng/ml (p.a.=0.612), creatine phosphokinase myocardial fraction at baseline 2.0 ng/ml (p.a.=0.721), creatine phosphokinase myocardial fraction at 6 h 2.5 ng/ml (p.a.=0.734), myoglobin at baseline 23 ng/ml (p.a.=0.623), myoglobin at 6 h 26 ng/ml (p.a.=0.617), C-reactive protein at baseline 0.31 mg/dl (p.a.=0.662), C-reactive protein at 6 h 0.55 mg/dl (p.a.=0.682), and fibrinogen at baseline 360 mg/dl (p.a.=0.701).
Positive_regulation (calculated) of Gene_expression (fraction) of C-reactive protein
19) Confidence 0.02 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771924 Disease Relevance 0.16 Pain Relevance 0
RESULTS: The following cut-off values for prediction of cardiac events were calculated: troponin I at baseline 0.3 ng/ml (predictive accuracy=0.870), troponin I at 6 h 0.50 ng/ml (p.a.=0.909); troponin T at baseline 0.05 ng/ml (p.a.=0.643), troponin T at 6 h 0.05 ng/ml (p.a.=0.612), creatine phosphokinase myocardial fraction at baseline 2.0 ng/ml (p.a.=0.721), creatine phosphokinase myocardial fraction at 6 h 2.5 ng/ml (p.a.=0.734), myoglobin at baseline 23 ng/ml (p.a.=0.623), myoglobin at 6 h 26 ng/ml (p.a.=0.617), C-reactive protein at baseline 0.31 mg/dl (p.a.=0.662), C-reactive protein at 6 h 0.55 mg/dl (p.a.=0.682), and fibrinogen at baseline 360 mg/dl (p.a.=0.701).
Positive_regulation (calculated) of Gene_expression (fraction) of C-reactive protein
20) Confidence 0.02 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771924 Disease Relevance 0.16 Pain Relevance 0

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