INT269961

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 16
Disease Relevance 14.28
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxb8) DNA binding (Hoxb8)
Anatomy Link Frequency
basal ganglia 2
brain stem 2
cortex 2
olfactory bulb 2
hippocampus 2
Hoxb8 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 14 98.44 Very High Very High Very High
sSRI 476 90.64 High High
Inflammation 128 87.72 High High
Clonidine 28 86.48 High High
Serotonin 154 66.56 Quite High
Inflammatory mediators 4 60.00 Quite High
Central nervous system 14 55.12 Quite High
cytokine 8 47.96 Quite Low
amygdala 84 34.28 Quite Low
dopamine receptor 42 20.80 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 2926 99.04 Very High Very High Very High
Targeted Disruption 152 98.96 Very High Very High Very High
Skin Abnormalities 14 92.92 High High
Aggression 28 91.32 High High
INFLAMMATION 138 87.72 High High
Apoptosis 222 86.20 High High
Tourette's Syndrome 126 85.44 High High
Lifespan 8 79.36 Quite High
Infection 92 78.08 Quite High
Bacterial Meningitis 28 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such broad expression of Hoxb8 throughout the adult brain may also account for possible atypical features that could be unrelated to OCD, such as the observed excessive grooming of wild-type cage mates, which in principle could represent abnormal aggression.
Gene_expression (expression) of Hoxb8 in adult brain associated with aggression and anxiety disorder
1) Confidence 0.69 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.73 Pain Relevance 0.24
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expressed) of Hoxb8 in hippocampus associated with hippocampus
2) Confidence 0.69 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.92 Pain Relevance 0.26
The extensive expression of Hoxb8 in virtually all regions of the CSTC circuit that is disrupted in OCD indicates strong potential for the involvement of Hoxb8 gene disruption in forms of human OCD and/or TTM.
Gene_expression (expression) of Hoxb8 associated with anxiety disorder
3) Confidence 0.69 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.86 Pain Relevance 0.22
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expression) of Hoxb8 in hippocampus associated with hippocampus
4) Confidence 0.53 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.26
Hoxb8 neutrophil progenitors derived from WT and bcl2-transgenic mice as described in [22] were cultured in Optimem medium (Invitrogen, Karlsruhe, Germany) supplemented with 10% FCS (PAA, Cölbe, Germany), 30 µM ?
Gene_expression (progenitors) of Hoxb8 in neutrophil associated with targeted disruption
5) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2682662 Disease Relevance 1.02 Pain Relevance 0.18
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expressed) of Hoxb8 in basal ganglia associated with hippocampus
6) Confidence 0.23 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.92 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expressed) of Hoxb8 in cerebellum associated with hippocampus
7) Confidence 0.23 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.92 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expressed) of Hoxb8 in olfactory bulb associated with hippocampus
8) Confidence 0.23 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.92 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expressed) of Hoxb8 in brain stem associated with hippocampus
9) Confidence 0.23 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.92 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expressed) of Hoxb8 in cortex associated with hippocampus
10) Confidence 0.23 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.92 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expression) of Hoxb8 in brain stem associated with hippocampus
11) Confidence 0.18 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expression) of Hoxb8 in olfactory bulb associated with hippocampus
12) Confidence 0.18 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expression) of Hoxb8 in cerebellum associated with hippocampus
13) Confidence 0.18 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expression) of Hoxb8 in cortex associated with hippocampus
14) Confidence 0.18 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.26
Intriguingly, Hoxb8 is broadly expressed in adult brain, with expression in the olfactory bulb, basal ganglia, hippocampus, cortex, cerebellum, and brain stem [106].
Gene_expression (expression) of Hoxb8 in basal ganglia associated with hippocampus
15) Confidence 0.18 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.26
The retroviral expression vectors for HoxB8 and SCF-producing cells were provided my Dr.
Gene_expression (producing) of HoxB8
16) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2682662 Disease Relevance 0.58 Pain Relevance 0.09

General Comments

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