INT269970

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
CII 2
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 66 95.72 Very High Very High Very High
cytokine 27 83.32 Quite High
Inflammation 34 78.60 Quite High
tolerance 16 50.00 Quite Low
Inflammatory response 2 47.84 Quite Low
Inflammatory mediators 1 37.20 Quite Low
fibrosis 29 22.68 Low Low
rheumatoid arthritis 26 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 40 95.72 Very High Very High Very High
Arthritis 28 94.56 High High
Synovitis 2 80.36 Quite High
INFLAMMATION 31 78.60 Quite High
Immunization 22 77.20 Quite High
Pressure And Volume Under Development 18 65.44 Quite High
Disease 43 62.64 Quite High
Erythema 12 52.64 Quite High
Fibrosis 11 52.00 Quite High
Autoimmune Disease 14 47.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced CII antibody production and generation of Treg by treatment of CD40 siRNA
Positive_regulation (generation) of Positive_regulation (treatment) of CD40 siRNA in CII
1) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.91 Pain Relevance 0.19
In previous studies we demonstrated that chemical manipulation in DCs through inhibition of IKK, which is responsible for CD40 upregulation in DC, can result in generation of antigen-specific immune regulation and suppression of pathology in the CIA model [15].
Positive_regulation (responsible) of Positive_regulation (upregulation) of CD40 associated with arthritis
2) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.64 Pain Relevance 0.24
B activating stimuli such as stimulation of CD40 activate the non-canonical, or alternative, pathway in which activation of catalytic subunits CHUK results in the formation of NFKB2 (p52) from p100 and the generation of NFKB2-RELB heterodimers that target distinct ?
Positive_regulation (activate) of Positive_regulation (stimulation) of CD40
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.24 Pain Relevance 0.13

General Comments

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