INT270

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Context Info
Confidence 0.60
First Reported 1977
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 2.58
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOA) small molecule metabolic process (MAOA) oxidoreductase activity (MAOA)
Anatomy Link Frequency
brain 2
liver 1
cerebral cortex 1
platelets 1
cerebellar cortex 1
MAOA (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 41 100.00 Very High Very High Very High
sSRI 25 100.00 Very High Very High Very High
noradrenaline 16 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
agonist 21 99.96 Very High Very High Very High
Serotonin 37 99.66 Very High Very High Very High
depression 52 99.44 Very High Very High Very High
antagonist 4 99.44 Very High Very High Very High
Sumatriptan 23 99.08 Very High Very High Very High
adenocard 1 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 104 99.44 Very High Very High Very High
Anxiety Disorder 5 98.96 Very High Very High Very High
Schizophrenia 4 98.60 Very High Very High Very High
Drug Dependence 5 96.72 Very High Very High Very High
Alcohol Addiction 2 93.40 High High
Headache 64 93.08 High High
Mental Disorders 4 90.08 High High
Pulpitis 2 87.56 High High
Xerostomia 5 85.52 High High
Pain 4 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoamine oxidase A (MAOA) is the X-linked gene responsible for deamination and subsequent degradation of several neurotransmitters and other amines.
Regulation (responsible) of Monoamine oxidase A associated with neurotransmitter and monoamine
1) Confidence 0.60 Published 2004 Journal Hum. Genet. Section Abstract Doc Link 15349769 Disease Relevance 0.16 Pain Relevance 0.18
Monoamine oxidase A (MAOA) is the X-linked gene responsible for deamination and subsequent degradation of several neurotransmitters and other amines.
Regulation (responsible) of MAOA associated with neurotransmitter and monoamine
2) Confidence 0.60 Published 2004 Journal Hum. Genet. Section Abstract Doc Link 15349769 Disease Relevance 0.16 Pain Relevance 0.18
Effect of monoamine receptor agonists and antagonists on cyclic AMP accumulation in human cerebral cortex slices.
Regulation (Effect) of monoamine receptor in cerebral cortex associated with antagonist, agonist, cerebral cortex and monoamine
3) Confidence 0.45 Published 1977 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 23211 Disease Relevance 0 Pain Relevance 1.12
Accumulation of cyclic adenosine 3',5'-monophosphate in human cerebellar cortex slices: effect of monoamine receptor agonists and antagonists.
Regulation (effect) of monoamine receptor in cerebellar cortex associated with adenocard, antagonist, agonist and monoamine
4) Confidence 0.45 Published 1978 Journal Brain Res. Section Title Doc Link 203365 Disease Relevance 0 Pain Relevance 1.02
The data in this study therefore indicate that the enzyme MAO-A is the major enzyme responsible for the metabolism of sumatriptan in human liver.
Regulation (responsible) of MAO in liver associated with sumatriptan
5) Confidence 0.45 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 8161354 Disease Relevance 0 Pain Relevance 0.57
A Canadian multicentre placebo-controlled study of a fixed dose of brofaromine, a reversible selective MAO-A inhibitor, in the treatment of major depression.
Regulation (placebo-controlled) of MAO-A associated with depression
6) Confidence 0.44 Published 1994 Journal J Affect Disord Section Title Doc Link 7829762 Disease Relevance 0.36 Pain Relevance 0.28
Frovatriptan does not alter CYP450 isoenzymes or monoamine oxidase (MAO); thus drug interactions of frovatriptan are clinically insignificant.
Neg (not) Regulation (alter) of monoamine oxidase associated with monoamine
7) Confidence 0.39 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936266 Disease Relevance 0.26 Pain Relevance 0.26
MAO-A is primarily responsible for degrading serotonin and norepinephrine, as well as exogenous monoamines such as tyramine.
Regulation (responsible) of MAO associated with serotonin and monoamine
8) Confidence 0.36 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.19 Pain Relevance 0.43
Biological and behavioral consequences of alterations in monoamine oxidase activity.
Regulation (alterations) of monoamine oxidase associated with monoamine
9) Confidence 0.27 Published 1980 Journal Schizophr Bull Section Title Doc Link 6103577 Disease Relevance 0 Pain Relevance 0.26
Longer term alterations in MAO activity are accompanied by secondary, adaptational changes in neurotransmitter-related receptors, other enzymes, and additional cell functions in brain and other tissues.
Regulation (alterations) of MAO in brain associated with neurotransmitter
10) Confidence 0.27 Published 1980 Journal Schizophr Bull Section Abstract Doc Link 6103577 Disease Relevance 0 Pain Relevance 0.25
This study investigated for the first time the potential effects of cis- and trans-resveratrol (c-RESV and t-RESV) on noradrenaline (NA) and 5-hydroxytryptamine (5-HT) uptake by synaptosomes from rat brain, on 5-HT uptake by human platelets, and on monoamine oxidase (MAO) isoform activity.
Spec (investigated) Regulation (effects) of MAO in platelets associated with noradrenaline and monoamine
11) Confidence 0.27 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16631124 Disease Relevance 0 Pain Relevance 0.34
However, [3H]BFI binding is dramatically stimulated by TCP in human brain via a mechanism dependent on endogenous MAO activity.
Regulation (dependent) of MAO in brain
12) Confidence 0.27 Published 1997 Journal Life Sci. Section Abstract Doc Link 9048963 Disease Relevance 0 Pain Relevance 0.13
MAO activity assayed with 100 microM [14C]5HT or 10 microM [14C]PEA was sensitive to selective inhibitors of MAO A and MAO B, respectively.
Regulation (sensitive) of MAO
13) Confidence 0.27 Published 2009 Journal Med. Sci. Monit. Section Body Doc Link 19789505 Disease Relevance 0.09 Pain Relevance 0
The decrease in MAO B activity and lack of significant changes in MAO A activity may be associated with an anti-inflammatory response - inflamed pulp MAO A still effectively deaminates the inflammatory mediator 5HT, whereas inhibition of MAO B could result in some decrease of hydrogen peroxide generation, essential for the tissue damage in inflammation.


Regulation (changes) of MAO
14) Confidence 0.27 Published 2009 Journal Med. Sci. Monit. Section Body Doc Link 19789505 Disease Relevance 0.06 Pain Relevance 0
In addition, different clinical trials conducted to study the effects of CYP3A4, CYP2D6, and MAO-A on the pharmacokinetics of almotriptan confirmed the involvement of these enzymes in the metabolic clearance of this drug and that no dose changes are required in the presence of inhibitors of these enzymes.
Regulation (effects) of MAO-A
15) Confidence 0.26 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12642466 Disease Relevance 0.07 Pain Relevance 0.04
Hence, the overall tolerability of moclobemide is much better than that of imipramine as shown in earlier studies.23 Highly selective affinity towards MAO-A and almost no affinity for muscarinic, dopa-minergic, serotoninergic, opioid or benzodiazepine receptors might be responsible for its greater tolerability and fewer side-effects.
Spec (might) Regulation (responsible) of MAO associated with opioid
16) Confidence 0.24 Published 2005 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2918305 Disease Relevance 0.24 Pain Relevance 0.15
MAO-A is the principal enzyme responsible for initiating the biotransformation (Table I).
Regulation (responsible) of MAO
17) Confidence 0.11 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0.05 Pain Relevance 0.71
Indeed, IAAs act on a variety of 5-HT receptors, serotonin transporter, or MAO enzyme that are highly favorable molecular targets for treating depression, anxiety, schizophrenia, and other psychiatric disturbances (37).
Regulation (targets) of MAO associated with depression, anxiety disorder, serotonin and schizophrenia
18) Confidence 0.07 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0.76 Pain Relevance 0.30
Most of these studies focus on candidate genes related to monoamine function, including the serotonin transporter (the molecular target for SSRIs), tryptophan hydroxylase-1, monoamine oxidase A, and the type 2A serotonin receptor.
Regulation (target) of monoamine oxidase associated with ssri, serotonin and monoamine
19) Confidence 0.05 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2965366 Disease Relevance 0.18 Pain Relevance 0.62

General Comments

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