INT270038

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 62 59.16 Quite High
Demyelination 12 44.96 Quite Low
Endocannabinoid 7 21.80 Low Low
agonist 6 17.12 Low Low
Inflammation 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Cannabinoid 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 96.00 Very High Very High Very High
Targeted Disruption 13 72.96 Quite High
Demyelinating Disease 84 59.16 Quite High
Wallerian Degeneration 1 55.20 Quite High
Disease 16 52.40 Quite High
Dyslipidemia /

Combined Dyslipidemia

5 50.04 Quite High
Multiple Sclerosis 35 46.56 Quite Low
Disorder Of Lipid Metabolism 4 36.56 Quite Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vaticanol C did not activate SIRT1 whereas resveratrol activated SIRT1 by the assay utilizing a fluorophore-containing peptide (Figure 2C).
Neg (not) Positive_regulation (activate) of Positive_regulation (activated) of SIRT1
1) Confidence 0.43 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.27 Pain Relevance 0
is mediated via NAD-dependent activation of SIRT-1.
Positive_regulation (mediated) of Positive_regulation (activation) of SIRT-1
2) Confidence 0.15 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.11 Pain Relevance 0.03

General Comments

This test has worked.

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