INT270044

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.59
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) intracellular (Il10) enzyme binding (Hmox1)
signal transducer activity (Hmox1) cytosol (Hmox1) extracellular space (Il10)
Il10 (Mus musculus)
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 124 89.72 High High
Demyelination 24 88.24 High High
Endocannabinoid 14 51.04 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Cannabinoid 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 168 89.72 High High
Multiple Sclerosis 70 86.88 High High
Disorder Of Lipid Metabolism 8 25.00 Low Low
Toxicity 2 25.00 Low Low
Lipodystrophy 2 25.00 Low Low
Dementia 2 25.00 Low Low
Disease 18 5.00 Very Low Very Low Very Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of action (MOA) is now known to involve induction of indoleamine 2,3-dioxygenase (IDO) and interleukin-10 (IL-10), where IL-10 requires subsequent heme oxygenase-1 (HMOX-1) induction.
IL-10 Positive_regulation (requires) of Positive_regulation (induction) of heme oxygenase-1
1) Confidence 0.20 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2683338 Disease Relevance 0.80 Pain Relevance 0.26
The mechanism of action (MOA) is now known to involve induction of indoleamine 2,3-dioxygenase (IDO) and interleukin-10 (IL-10), where IL-10 requires subsequent heme oxygenase-1 (HMOX-1) induction.
IL-10 Positive_regulation (requires) of Positive_regulation (induction) of HMOX-1
2) Confidence 0.16 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2683338 Disease Relevance 0.80 Pain Relevance 0.26

General Comments

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