INT270046

Context Info Confidence 0.15 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.80 Pain Relevance 0.27

cytosol (Ido1, Hmox1) oxidoreductase activity (Ido1, Hmox1) endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1) cytoplasm (Ido1)

Ido1 (Mus musculus) Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat Multiple sclerosis 62 91.28 Demyelination 12 88.24 Endocannabinoid 7 51.04 Inflammation 6 5.00 rheumatoid arthritis 4 5.00 cytokine 3 5.00 dexamethasone 2 5.00 agonist 2 5.00 Cannabinoid 2 5.00 corticosteroid 1 5.00

Disease Link Frequency Relevance Heat Demyelinating Disease 84 91.28 Multiple Sclerosis 35 86.88 Disorder Of Lipid Metabolism 4 25.00 Toxicity 1 25.00 Lipodystrophy 1 25.00 Dementia 1 25.00 Disease 9 5.00 Autoimmune Disease 7 5.00 INFLAMMATION 6 5.00 Death 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mechanism of action (MOA) is now known to involve induction of indoleamine 2,3-dioxygenase (IDO) and interleukin-10 (IL-10), where IL-10 requires subsequent heme oxygenase-1 (HMOX-1) induction.

IDO Positive_regulation (requires) of Positive_regulation (induction) of heme oxygenase-1

1) Confidence 0.15 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2683338 Disease Relevance 0.80 Pain Relevance 0.27

General Comments

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