INT270065

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.11
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (HOXD12) nucleus (HOXD12)
HOXD12 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 205 99.62 Very High Very High Very High
Neurotransmitter 155 98.76 Very High Very High Very High
substance P 120 98.52 Very High Very High Very High
Serotonin 10 97.32 Very High Very High Very High
Catecholamine 25 97.12 Very High Very High Very High
Glutamate 125 97.08 Very High Very High Very High
GABAergic 35 94.32 High High
Central nervous system 10 92.48 High High
cytokine 10 91.76 High High
Inflammation 10 91.40 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 95 98.94 Very High Very High Very High
INFLAMMATION 10 91.40 High High
Disease 25 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that D12 induced MSCs are capable of releasing neurotransmitter in response to membrane depolarization by KCl (10).
Positive_regulation (induced) of D12 associated with neurotransmitter
1) Confidence 0.05 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.39 Pain Relevance 1.11
Uninduced (D0) and induced (D12) MSCs were stimulated with IL-1?
Positive_regulation (induced) of D12
2) Confidence 0.05 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.09 Pain Relevance 0.51
Uninduced (D0) and induced (D12) MSCs were stimulated with IL-1?
Positive_regulation (Uninduced) of D12
3) Confidence 0.05 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.09 Pain Relevance 0.52
Only GAD, the rate-limiting enzyme in GABA biosynthesis, was upregulated in the D12 cells (Fig. 2A).
Positive_regulation (upregulated) of D12 associated with gaba
4) Confidence 0.04 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.19 Pain Relevance 1.06
To this end, expression of the rate-limiting enzymes in catecholamine (TyrH), serotonin (TrypH) and GABA (GAD) biosynthesis, as well as the vesicular acetylcholine transporter (VAChT), were examined in uninduced (D0) and induced (D6 and D12) MSCs (Fig. 2A).
Positive_regulation (induced) of D12 associated with gaba, catecholamine and serotonin
5) Confidence 0.04 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.35 Pain Relevance 0.67

General Comments

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