INT270102

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5) small molecule metabolic process (ALOX5) endoplasmic reticulum (PLA2G2A)
cytoplasm (ALOX5) cytosol (ALOX5) extracellular space (PLA2G2A)
Anatomy Link Frequency
endocrine system 1
ALOX5 (Homo sapiens)
PLA2G2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 88.96 High High
Osteoarthritis 32 74.08 Quite High
licofelone 45 73.56 Quite High
Pain 3 68.56 Quite High
cINOD 16 49.44 Quite Low
Pain score 2 38.88 Quite Low
aspirin 6 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 88.96 High High
Osteoarthritis 33 74.08 Quite High
Pain 5 68.56 Quite High
Pressure And Volume Under Development 3 58.60 Quite High
Cancer 1 5.92 Low Low
Arthritis 7 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Ulcers 5 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pharmacological profile of LOX/COX inhibitors is quite similar to that of glucocorticoids drugs, which inhibit PLA2 and thereby prevent arachidonic metabolism by both COX and 5-LOX, without the severe adverse events on the endocrine system and on the metabolism intermediates of PLA2, normally associated with the use of these steroid drugs (Parente 2001).
5-LOX Negative_regulation (inhibit) of PLA2 in endocrine system
1) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.49 Pain Relevance 0.57

General Comments

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