INT270125

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.76
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
neuronal 1
dentate gyrus 1
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
Hippocampus 10 34.88 Quite Low
noradrenaline 2 26.64 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 148 87.12 High High
Alzheimer's Dementia 10 83.68 Quite High
Hypertension 8 82.68 Quite High
Amyloid Plaque 8 77.76 Quite High
Disease Progression 2 74.96 Quite High
Drug Induced Neurotoxicity 4 73.44 Quite High
Pressure And Volume Under Development 2 62.84 Quite High
Frailty 2 52.32 Quite High
Cognitive Disorder 70 44.16 Quite Low
Cardiovascular Disease 2 40.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with saline-treated rats, the rats subchronically (3 days) and chronically (21 days), but not acutely, treated with rivastigmine showed a significant increase in rEAAC1 mRNA expression in the hippocampal areas cornu anterior 1 (CA1), CA2, CA3 and dentate gyrus (p<0.01), but not in cortical areas.
Transcription (expression) of rEAAC1 in dentate gyrus
1) Confidence 0.10 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684084 Disease Relevance 0.80 Pain Relevance 0.04
An in situ hybridization technique (using digoxigenin-labeled cRNA probes) was used to elucidate changes in mRNA expression of the neuronal glutamate transporter, rat excitatory amino carrier 1 (rEAAC1), after treatment with the AChEl rivastigmine.
Transcription (expression) of rEAAC1 in neuronal associated with glutamate
2) Confidence 0.08 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684084 Disease Relevance 0.96 Pain Relevance 0.05

General Comments

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