INT270134

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.36 Pain Relevance 0.05

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS) nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)

Anatomy Link Frequency osteoclast 1 BPs (Homo sapiens) FDPS (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 3 96.96 adenocard 1 18.40 withdrawal 1 8.68 cytokine 6 5.00 agonist 2 5.00 backache 1 5.00 cva 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Postmenopausal Osteoporosis 4 79.56 Hypercalcemia 10 75.68 Apoptosis 3 75.12 Osteoporosis 28 75.04 Adhesions 1 54.08 Death 1 10.40 Endometriosis (extended) 4 7.56 Disease 4 5.00 Breast Cancer 3 5.00 Cognitive Disorder 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nitrogen-containing BPs (N-BPs) reduce osteoclast function by inhibiting farnesyl diphosphate synthase, an enzyme which is active in the mevalonate pathway of the cholesterol biosynthesis.

BPs Negative_regulation (inhibiting) of farnesyl diphosphate synthase in osteoclast

1) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.36 Pain Relevance 0.05

General Comments

This test has worked.