INT270134

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS)
nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)
Anatomy Link Frequency
osteoclast 1
BPs (Homo sapiens)
FDPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 96.96 Very High Very High Very High
adenocard 1 18.40 Low Low
withdrawal 1 8.68 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Postmenopausal Osteoporosis 4 79.56 Quite High
Hypercalcemia 10 75.68 Quite High
Apoptosis 3 75.12 Quite High
Osteoporosis 28 75.04 Quite High
Adhesions 1 54.08 Quite High
Death 1 10.40 Low Low
Endometriosis (extended) 4 7.56 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitrogen-containing BPs (N-BPs) reduce osteoclast function by inhibiting farnesyl diphosphate synthase, an enzyme which is active in the mevalonate pathway of the cholesterol biosynthesis.
BPs Negative_regulation (inhibiting) of farnesyl diphosphate synthase in osteoclast
1) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.36 Pain Relevance 0.05

General Comments

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