INT270150

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Anatomy Link Frequency
neutrophils 2
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 5 91.68 High High
cytokine 56 90.56 High High
Central nervous system 23 48.80 Quite Low
Inflammation 46 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 26 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Aging 103 99.96 Very High Very High Very High
Autoimmune Disease 18 91.56 High High
Apoptosis 34 71.04 Quite High
Systemic Lupus Erythematosus 30 67.16 Quite High
Burns 1 55.84 Quite High
General Immunology 1 43.88 Quite Low
Hypertrophy 2 40.64 Quite Low
Influenza Virus Infection 15 31.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Honda and Taniguchi reported that type I IFN induction was mediated trough TLR signaling, which stimulated sequential activation of adaptors and kinases of the IRAK, IKK and TRAF families, and then leading to the activation of IRF5 and IRF7 [44], [45].
Positive_regulation (stimulated) of Positive_regulation (activation) of IRAK
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.23 Pain Relevance 0
This event allows activation of the IL-1R-associated kinase (IRAK)/tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway leading to nuclear translocation of the nuclear factor kappa beta (NF-?
Positive_regulation (pathway) of Positive_regulation (activation) of IRAK associated with necrosis and cancer
2) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.20 Pain Relevance 0
The displacement of TLRs to lipid rafts in neutrophils is deficient with aging, leading to an alteration of IRAK activation (Fulop et al 2004).
Positive_regulation (leading) of Positive_regulation (activation) of IRAK in neutrophils associated with aging
3) Confidence 0.15 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.48 Pain Relevance 0.09

General Comments

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