INT270152

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 19
Disease Relevance 11.10
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lat) plasma membrane (Lat) intracellular (Lat)
Anatomy Link Frequency
LAT 1
Lat (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 89.92 High High
agonist 28 68.40 Quite High
cytokine 29 66.64 Quite High
monoamine 14 22.80 Low Low
ketamine 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
adenocard 13 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 630 99.18 Very High Very High Very High
Cold Sores 1248 99.00 Very High Very High Very High
Thrombosis 4 88.28 High High
Hemorrhage 4 87.00 High High
Eye Infections 14 85.48 High High
Infection 177 84.56 Quite High
Adhesions 10 62.24 Quite High
Aging 103 56.60 Quite High
Herpes Simplex Virus 15 53.64 Quite High
Death 17 35.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are in line with those for aggregation and secretion, with minor and major roles for Gads and LAT, respectively, in regulating phosphorylation of PLC?
Positive_regulation (roles) of LAT
1) Confidence 0.44 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.05 Pain Relevance 0
This reduction is most likely due to increased accessibility of tyrosine residues in Syk to protein tyrosine phosphatases in the absence of LAT.
Positive_regulation (absence) of LAT
2) Confidence 0.44 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.18 Pain Relevance 0
In the absence of LAT, a limited degree of tyrosine phosphorylation activation of PLC?
Positive_regulation (activation) of LAT
3) Confidence 0.41 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.16 Pain Relevance 0
In comparison to LAT and SLP-76, Gads has a relatively minor role in recruiting SLP-76 to LAT and activation of PLC?
Positive_regulation (activation) of LAT
4) Confidence 0.41 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.15 Pain Relevance 0.03
In contrast, when the same experimental protocol was applied to rabbits latent with HSV-1 strain KOS, with the goal being to determine whether we could observe a difference in the patterns of enrichment of H3K4me2 associated with the LAT region of KOS following TCIE of latently infected rabbits, we found no significant change (either increase or decrease) in the overall enrichment of H3K4me2 for the LAT 5?
Positive_regulation (enrichment) of LAT 5 associated with cold sores and sprains and strains
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.93 Pain Relevance 0
Latently infected rabbits were subjected to TCIE and the H3K4me2 enrichment of the reactivation critical LAT 5?
Positive_regulation (reactivation) of LAT 5
6) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.64 Pain Relevance 0
The fact that we can observe these epigenetic changes in the reactivation critical LAT 5?
Positive_regulation (reactivation) of LAT 5
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.39 Pain Relevance 0
Taking into consideration the proximity and spatial arrangement of the IE promoters to the LAT, and specifically to the reactivation critical LAT 5?
Positive_regulation (critical) of LAT 5
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.84 Pain Relevance 0
Critical examples include findings that show that during latency the LAT promoter and the LAT 5?
Positive_regulation (latency) of LAT 5
9) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.01 Pain Relevance 0
In summary, our results showed that enrichments of H3K4me2 on the LAT 5?
Positive_regulation (enrichments) of LAT 5
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.64 Pain Relevance 0
Critical examples include findings that show that during latency the LAT promoter and the LAT 5?
Positive_regulation (latency) of LAT promoter
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.01 Pain Relevance 0
5-fold decrease (P<0.09) in the LAT RNA accumulation by 1 h post-TCIE, and a significant decrease (?
Positive_regulation (accumulation) of LAT RNA
12) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.85 Pain Relevance 0
Taking into consideration the proximity and spatial arrangement of the IE promoters to the LAT, and specifically to the reactivation critical LAT 5?
Positive_regulation (reactivation) of LAT 5
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.84 Pain Relevance 0
The reactivation critical LAT 5?
Positive_regulation (reactivation) of LAT 5
14) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.43 Pain Relevance 0
These changes in H3K4me2 enrichment correlated to significant decreased LAT RNA accumulation and a 2–6 fold increase in ICP4 transcript abundance following TCIE.
Positive_regulation (accumulation) of LAT RNA
15) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.56 Pain Relevance 0
These findings confirm that a correlation exists between the loss of euchromatic histone mark enrichment and the subsequent decrease in LAT RNA accumulation at very early times following the application of a reactivation stimulus in the rabbit model.
Positive_regulation (accumulation) of LAT RNA
16) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.68 Pain Relevance 0
10-fold) in the accumulation of LAT RNA by 2 h post-TCIE (P<0.05) compared to the latent values in the rabbits latent with the efficient reactivator McKrae.
Positive_regulation (accumulation) of LAT RNA
17) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.85 Pain Relevance 0
On the other hand, examination of the RNA accumulation by qRT-PCR following TCIE in rabbits latently infected with HSV-1 strain KOS showed no significant change in the accumulation of LAT RNA through 4 h post-TCIE when compared to latent values in the KOS strain of HSV-1 (Fig. 4D).
Positive_regulation (accumulation) of LAT RNA associated with cold sores and sprains and strains
18) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.77 Pain Relevance 0
Following their coalescence the molecule Lck is autophosphorylated, activating ZAP-70 and leading to the activation of linker of activated T cells (LAT).
Positive_regulation (activation) of LAT in LAT
19) Confidence 0.21 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.12 Pain Relevance 0.12

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