INT27018

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 68
Total Number 68
Disease Relevance 31.76
Pain Relevance 20.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1) signal transducer activity (PTGER1)
Anatomy Link Frequency
macrophages 3
muscle 3
nerves 3
fibroblasts 2
blood 2
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatic nerve 96 100.00 Very High Very High Very High
bradykinin 16 100.00 Very High Very High Very High
Pain 310 99.92 Very High Very High Very High
Dynorphin 2 99.86 Very High Very High Very High
cytokine 85 99.84 Very High Very High Very High
COX2 32 99.84 Very High Very High Very High
Kinase C 12 99.84 Very High Very High Very High
hyperexcitability 10 99.66 Very High Very High Very High
Inflammation 479 99.64 Very High Very High Very High
Dopamine 2 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myalgia 4 99.92 Very High Very High Very High
Stress 18 99.78 Very High Very High Very High
INFLAMMATION 599 99.64 Very High Very High Very High
Rheumatoid Arthritis 47 99.58 Very High Very High Very High
Pain 296 99.54 Very High Very High Very High
Colorectal Cancer 252 99.48 Very High Very High Very High
Cancer 410 99.08 Very High Very High Very High
Gallbladder Disease 5 99.00 Very High Very High Very High
Alzheimer's Dementia 9 98.88 Very High Very High Very High
Injury 211 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, contractile PGE2-EP1 and thromboxane TP receptors were expressed in ureteral smooth muscle.
Gene_expression (expressed) of EP1 in smooth muscle
1) Confidence 0.75 Published 2006 Journal Kidney Int. Section Abstract Doc Link 16820795 Disease Relevance 0.06 Pain Relevance 0.03
In the absence of epithelial Stat3 expression, this results in the formation of occasional low-grade intraepithelial neoplastic lesions, while epithelial Stat3 proficiency enables progression of these lesions into advanced tubular tumors [68,84].
Gene_expression (expression) of epi associated with cancer
2) Confidence 0.75 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.25 Pain Relevance 0.17
Tumor growth, with and without provision of a classical cyclo-oxygenase inhibitor (indomethacin), was related to tumor content of COX-1/COX-2 protein as well as to EP1-EP4 and prostacyclin receptor expression.
Gene_expression (expression) of EP1 associated with cancer
3) Confidence 0.75 Published 2005 Journal Int. J. Oncol. Section Abstract Doc Link 16142306 Disease Relevance 1.19 Pain Relevance 0.34
Thus, the observed altered expression of EP receptor subtypes in CRC patients compared to non-CRC subjects does not seem to be manifest in the functionality of the receptors in epithelial transport.
Gene_expression (expression) of EP receptor associated with colorectal cancer
4) Confidence 0.58 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.65 Pain Relevance 0.17
A time course analysis of EP1-IR:NF-IR ratio and Cox-2-IR in human brachial plexus nerves showed that EP1 expression preceded Cox-2-IR increased levels (Figure 3).
Gene_expression (expression) of EP1 in nerves
5) Confidence 0.56 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.13 Pain Relevance 0.06
However, in the present study, we found EP1 receptors to be mainly expressed in axons and cell bodies of human sensory neurones.
Gene_expression (expressed) of EP1
6) Confidence 0.56 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.65 Pain Relevance 0.53
The molecular regulators of EP1 expression in DRG neurons are unknown – trauma and initial inflammatory response (shown by rapid increases of CD68-IR) may lead to increased EP1 levels, to which PGs may contribute.
Gene_expression (expression) of EP1 in neurons associated with inflammatory response and injury
7) Confidence 0.56 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.77 Pain Relevance 0.59
EP1 and NF-immunoreactive nerve fibres were quantified by image analysis (% immunopositive area) in injured and control nerves and expressed as the ratio EP1:NF (Figure 2).
Gene_expression (expressed) of EP1 in nerves
8) Confidence 0.56 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.09 Pain Relevance 0
Of the four employed EP receptor agonists, PGE2 induced the largest increase in SCC (i.e. electrogenic secretion), which is not surprising as PGE2 stimulates all four EP receptor subtypes.
Neg (not) Gene_expression (stimulates) of EP receptor associated with agonist
9) Confidence 0.50 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0 Pain Relevance 0.05
In human DRG, EP1 immunoreactivity (EP1-IR) was detected in small/medium diameter neurones of control (Figure 1C) and injured human DRG (Figure 1D).
Gene_expression (detected) of EP1
10) Confidence 0.49 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.08 Pain Relevance 0
In human DRG, EP1 immunoreactivity (EP1-IR) was detected in small/medium diameter neurones of control (Figure 1C) and injured human DRG (Figure 1D).
Gene_expression (detected) of EP1
11) Confidence 0.49 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.08 Pain Relevance 0
In a rodent partial nerve ligation study, EP1-IR was found near the sciatic nerve ligation site, in nuclei of cells co-expressing the macrophage marker ED1 [51].
Gene_expression (expressing) of EP1 in macrophage associated with sciatic nerve
12) Confidence 0.49 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.58 Pain Relevance 0.54
PGE(2), ATP, and a combination of Bk, 5-HT, His, and PGE(2) produced the intended moderate pain.
Gene_expression (produced) of PGE associated with pain and bradykinin
13) Confidence 0.46 Published 2003 Journal Eur J Pain Section Abstract Doc Link 12600796 Disease Relevance 0.67 Pain Relevance 0.93
PGE(2), ATP, and a combination of Bk, 5-HT, His, and PGE(2) produced the intended moderate pain.
Gene_expression (produced) of PGE associated with pain and bradykinin
14) Confidence 0.46 Published 2003 Journal Eur J Pain Section Abstract Doc Link 12600796 Disease Relevance 0.67 Pain Relevance 0.92
Our findings indicate that normally appearing colon in CRN patients, including CRC patients, express higher COX enzyme activity than in control patients but with no difference in the functional expression of the four EP receptor subtypes with respect to transepithelial ion transport.


Gene_expression (expression) of EP receptor in colon associated with colorectal cancer
15) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.73 Pain Relevance 0.25
This indicates that increased indomethacin-sensitive mechanisms in colonic mucosa from neoplasia diseased patients are not related to differences in functional expression of EP receptor subtypes.



Gene_expression (expression) of EP receptor associated with cancer
16) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2824707 Disease Relevance 0.33 Pain Relevance 0.04
We hypothesized that patients with colonic neoplasia have altered colonic epithelial ion transport and express functionally different prostanoid receptor levels in this respect.


Gene_expression (express) of prostanoid receptor associated with cancer
17) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2824707 Disease Relevance 0.44 Pain Relevance 0
The mode of action for the observed effect of indomethacin does not seem related to the functionality of expressed prostaglandin EP receptor subtypes, EP1-4, when compared with non-neoplastic patient tissues.
Gene_expression (expressed) of EP1-4
18) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.61 Pain Relevance 0.22
In this regard it will be intriguing to investigate how PGE2 itself regulates the expression of the distinct EP receptor isoforms and splice variants.
Gene_expression (expression) of EP receptor
19) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.40 Pain Relevance 0.05
The results of this analysis, shown in Fig. 7A, evidenced that HT-29 cells express EP1, EP2 and EP4 receptors but no EP3.
Neg (no) Gene_expression (express) of EP1 in HT-29
20) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.07 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox