INT270188

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.91
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SYCP3) cell cycle (SYCP3) DNA binding (SYCP3)
cell division (SYCP3)
Anatomy Link Frequency
CD86 1
telomere 1
T cells 1
SYCP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 82 78.48 Quite High
antagonist 19 57.28 Quite High
chemokine 21 56.72 Quite High
cytokine 87 23.48 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 309 98.40 Very High Very High Very High
Apoptosis 93 95.76 Very High Very High Very High
INFLAMMATION 100 78.48 Quite High
Stress 24 69.32 Quite High
Disease 76 62.88 Quite High
Autoimmune Disease 33 61.52 Quite High
Cytomegalovirus Infection 24 53.04 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 63 50.40 Quite High
Death 51 49.80 Quite Low
Cancer 72 36.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, although CD8+ T cells lose their CD28 co-receptor more readily, they are intrinsically less dependent on CD28 for activation than CD4+ T cells (Larbi, Muti, et al 2006).
Negative_regulation (lose) of co-receptor in T cells
1) Confidence 0.42 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.96 Pain Relevance 0
The loss of the CD28 co-receptor provides an explanation for the telomere shortening and proliferation arrest because signaling via this molecule is essential for telomerase induction and prevention of telomere shortening (Pawelec 2000).
Negative_regulation (loss) of co-receptor in telomere
2) Confidence 0.42 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.31 Pain Relevance 0
Probably the numbers of major histocompatibility complex (MHC)-II, CD80, and CD86 co-receptors on APC do not change appreciably with aging, according to most available data.
Negative_regulation (numbers) of co-receptor in CD86 associated with aging
3) Confidence 0.42 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.59 Pain Relevance 0.08
Amongst these candidates the drugs that are farthest along in clinical development include the fusion inhibitors and the CCR5 coreceptor inhibitors.
Negative_regulation (inhibitors) of coreceptor
4) Confidence 0.42 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.05 Pain Relevance 0.06

General Comments

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