INT270217

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.63
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
cellular_component (C2) response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
neuronal 2
C2 (Rattus norvegicus)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 20 87.72 High High
Eae 8 78.40 Quite High
dorsal root ganglion 154 76.80 Quite High
Neurotransmitter 2 65.52 Quite High
Neuropathic pain 26 58.12 Quite High
Brush evoked pain 38 53.80 Quite High
Root ganglion neuron 2 50.00 Quite Low
Pain 16 46.84 Quite Low
agonist 10 21.44 Low Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 88 87.72 High High
Inflammatory Pain 2 78.40 Quite High
Ganglion Cysts 156 76.80 Quite High
Nociception 2 74.16 Quite High
Neuropathic Pain 70 58.12 Quite High
Pain 18 46.84 Quite Low
Injury 10 40.32 Quite Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While cPLA2 is distributed throughout the cytoplasm in the normal condition, in response to a variety of extracellular stimuli, an increase in intracellular Ca2+ concentration promotes binding of Ca2+ to the C2 domain and then allows cPLA2 to translocate to the perinuclear region, including the nuclear envelope, Golgi apparatus and endoplasmic reticulum in non-neuronal cells [27-31].
C2 Binding (binding) of Ca2 in neuronal
1) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.79 Pain Relevance 0.39
While cPLA2 is distributed throughout the cytoplasm in the normal condition, in response to a variety of extracellular stimuli, an increase in intracellular Ca2+ concentration promotes binding of Ca2+ to the C2 domain and then allows cPLA2 to translocate to the perinuclear region, including the nuclear envelope, Golgi apparatus and endoplasmic reticulum in non-neuronal cells [27-31].
C2 Binding (binding) of Ca2 in neuronal
2) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.84 Pain Relevance 0.42

General Comments

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