INT270224

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Context Info
Confidence 0.62
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.63
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) aging (Pla2g4a) Golgi apparatus (Pla2g4a)
endoplasmic reticulum (Pla2g4a) cytoplasmic membrane-bounded vesicle (Pla2g4a) nucleus (Pla2g4a)
Anatomy Link Frequency
nerve 6
spinal nerve 2
neurons 2
peripheral nerve 2
Pla2g4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 60 99.90 Very High Very High Very High
dorsal root ganglion 462 99.84 Very High Very High Very High
Brush evoked pain 114 97.32 Very High Very High Very High
Pain 48 95.04 Very High Very High Very High
Neuropathic pain 78 92.40 High High
Eae 24 90.48 High High
Neurotransmitter 6 77.60 Quite High
Root ganglion neuron 6 75.00 Quite High
withdrawal 18 59.00 Quite High
agonist 30 33.52 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 264 99.98 Very High Very High Very High
Ganglion Cysts 468 99.84 Very High Very High Very High
Neuropathic Pain 210 97.32 Very High Very High Very High
Pain 54 95.04 Very High Very High Very High
Inflammatory Pain 6 90.48 High High
Nociception 6 86.24 High High
Injury 30 32.76 Quite Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it raises the possibility that peripheral nerve injury may induce the activation of cPLA2 via the phosphorylation of MAPKs and CaMKII in primary afferent neurons, but their roles remain to be determined.
Positive_regulation (induce) of Positive_regulation (activation) of cPLA2 in peripheral nerve associated with nervous system injury and peripheral nerve injury
1) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.92 Pain Relevance 0.46
A CaMKII inhibitor suppresses nerve injury-induced cPLA2 activation
Positive_regulation (induced) of Positive_regulation (activation) of cPLA2 in nerve associated with nervous system injury
2) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.16 Pain Relevance 0.41
These results indicate that p38 and ERK are not involved in nerve injury-induced cPLA2 activation in DRG neurons.


Neg (not) Positive_regulation (induced) of Positive_regulation (activation) of cPLA2 in nerve associated with dorsal root ganglion and nervous system injury
3) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.14 Pain Relevance 0.44
To further test whether the inhibition of CaMKII activation affects nerve injury-induced cPLA2 activation, we injected a CaMKII inhibitor, KN-93, and a negative control for KN-93, KN-92, into nerve-injured rats.
Positive_regulation (induced) of Positive_regulation (activation) of cPLA2 in nerve associated with nervous system injury
4) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.10 Pain Relevance 0.41
We have previously shown that spinal nerve injury induces the activation of cytosolic phospholipase A2 (cPLA2), a Ca2+-dependent subclass of the PLA2 family [1], in DRG neurons, and that inhibiting cPLA2 suppresses nerve injury-induced tactile allodynia, revealing a crucial role for this enzyme in neuropathic pain [2].
Positive_regulation (induces) of Positive_regulation (activation) of cPLA2 in spinal nerve associated with brush evoked pain, dorsal root ganglion, nervous system injury and neuropathic pain
5) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.03 Pain Relevance 0.69
We have previously shown that spinal nerve injury induces the activation of cytosolic phospholipase A2 (cPLA2) in injured dorsal root ganglion (DRG) neurons that contribute to tactile allodynia.
Positive_regulation (induces) of Positive_regulation (activation) of cPLA2 in neurons associated with ganglion cysts, brush evoked pain, dorsal root ganglion and nervous system injury
6) Confidence 0.42 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2684092 Disease Relevance 1.28 Pain Relevance 0.80

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