INT270238

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 17.99
Pain Relevance 11.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) aging (Pla2g4a) Golgi apparatus (Pla2g4a)
endoplasmic reticulum (Pla2g4a) cytoplasmic membrane-bounded vesicle (Pla2g4a) nucleus (Pla2g4a)
Anatomy Link Frequency
neurons 7
plasma 4
nerve 1
peripheral nerve 1
DRG 1
Pla2g4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 1155 99.84 Very High Very High Very High
Brush evoked pain 285 99.66 Very High Very High Very High
Neuropathic pain 195 99.44 Very High Very High Very High
Peripheral nerve injury 150 98.40 Very High Very High Very High
Pain 120 88.64 High High
Inflammation 30 88.44 High High
agonist 75 83.68 Quite High
Central nervous system 15 83.52 Quite High
Nerve growth factor 45 81.04 Quite High
Sciatic nerve 15 78.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1170 99.84 Very High Very High Very High
Nervous System Injury 660 99.72 Very High Very High Very High
Neuropathic Pain 525 99.66 Very High Very High Very High
Pain 135 88.64 High High
INFLAMMATION 30 88.44 High High
Injury 75 73.60 Quite High
Hyperalgesia 15 68.12 Quite High
Inflammatory Pain 15 66.84 Quite High
Nociception 15 62.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that DRG neurons showing translocation of both phosphorylated cPLA2 and CaMKII to the plasma membrane were observed in the injured DRG.
Localization (translocation) of cPLA2 in plasma associated with dorsal root ganglion
1) Confidence 0.72 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.81 Pain Relevance 1.52
Importantly, pharmacological blockade of CaMKII prevented cPLA2 phosphorylation and translocation as well as tactile allodynia following peripheral nerve injury.
Localization (translocation) of cPLA2 in peripheral nerve associated with brush evoked pain, nervous system injury and peripheral nerve injury
2) Confidence 0.72 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.83 Pain Relevance 1.49
These results suggest that the phosphorylation and translocation of cPLA2 to the plasma membrane via an interaction with activated CaMKII is a key event in the development of nerve injury-induced tactile allodynia.
Localization (translocation) of cPLA2 in plasma associated with brush evoked pain and nervous system injury
3) Confidence 0.72 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.84 Pain Relevance 1.44
These results suggest that CaMKII is involved in cPLA2 phosphorylation and translocation in DRG neurons caused by nerve injury.
Localization (translocation) of cPLA2 in nerve associated with dorsal root ganglion and nervous system injury
4) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.30 Pain Relevance 0.56
The present study demonstrated that CaMKII, but not MAPKs, has an important role in cPLA2-dependent tactile allodynia via the regulation of phosphorylation and translocation of cPLA2, both of which are mediated by P2X3R/P2X2+3R and voltage-dependent Ca2+ channels in primary afferent neurons following peripheral nerve injury.
Localization (translocation) of cPLA2 in afferent neurons associated with brush evoked pain, nervous system injury and peripheral nerve injury
5) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.67 Pain Relevance 0.77
Pharmacological inhibition of either p38 or extracellular signal-regulated kinase (ERK) in the injured DRG, which led to suppression of the development of tactile allodynia, did not affect cPLA2 phosphorylation and translocation after nerve injury.
Localization (translocation) of cPLA2 in DRG associated with brush evoked pain, dorsal root ganglion and nervous system injury
6) Confidence 0.63 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2684092 Disease Relevance 1.67 Pain Relevance 0.93
Our results provide important evidence to help us to understand the mechanism underlying neuropathic pain modulated by cPLA2 and the translocation of cPLA2 and CaMKII in DRG neurons under pathophysiological conditions.


Localization (translocation) of cPLA2 in neurons associated with dorsal root ganglion and neuropathic pain
7) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.84 Pain Relevance 0.76
Therefore, the translocation of cPLA2 in DRG neurons seems to be unique, but the mechanism of cPLA2 translocation remains unknown.
Localization (translocation) of cPLA2 in neurons associated with dorsal root ganglion
8) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.94 Pain Relevance 0.34
Therefore, the translocation of cPLA2 in DRG neurons seems to be unique, but the mechanism of cPLA2 translocation remains unknown.
Localization (translocation) of cPLA2 in neurons associated with dorsal root ganglion
9) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.87 Pain Relevance 0.33
To investigate this hypothesis, we examined co-localization of phosphorylated cPLA2 and CaMKII in DRG neurons.
Localization (localization) of cPLA2 in neurons associated with dorsal root ganglion
10) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.25 Pain Relevance 0.45
By contrast, our previous study showed that phosphorylated cPLA2 translocates to the plasma membranes of injured DRG neurons.
Localization (translocates) of cPLA2 in plasma associated with dorsal root ganglion
11) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.78 Pain Relevance 0.33
The proportion of the p-cPLA2-translocated neurons to the total number of DRG neurons was determined in twenty randomly chosen sections from six rats in KN-92- and KN-93-treated groups.


Localization (translocated) of p-cPLA2 in neurons associated with dorsal root ganglion
12) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.75 Pain Relevance 0.29
Subsequently, activated CaMKII would phosphorylate cPLA2 and be translocated to the plasma membrane by interacting physically with activated cPLA2.
Localization (translocated) of cPLA2 in plasma
13) Confidence 0.55 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.65 Pain Relevance 0.69
By contrast, a CaMKII inhibitor prevented the development and expression of nerve injury-induced tactile allodynia and reduced both the level of cPLA2 phosphorylation and the number of DRG neurons showing translocated cPLA2 in response to nerve injury.
Localization (translocated) of cPLA2 in neurons associated with dorsal root ganglion, brush evoked pain and nervous system injury
14) Confidence 0.55 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2684092 Disease Relevance 1.58 Pain Relevance 0.87
To examine whether CaMKII is also activated by these receptors, we applied ATP to cultured DRG neurons and found that the level of p-CaMKII-IR was increased in the vicinity of the plasma membranes of DRG neurons, similar to the translocation of p-cPLA2 after applying ATP (Figure 5A).
Localization (translocation) of p-cPLA2 in neurons associated with dorsal root ganglion
15) Confidence 0.55 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.20 Pain Relevance 0.60

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