INT270304

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.15
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FMOD) extracellular region (FMOD) proteinaceous extracellular matrix (FMOD)
intracellular (FMOD)
Anatomy Link Frequency
nucleus 2
FMOD (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 147 100.00 Very High Very High Very High
Central nervous system 5 99.22 Very High Very High Very High
Neuropathic pain 2 98.06 Very High Very High Very High
depression 20 73.24 Quite High
cytokine 3 71.92 Quite High
Peripheral sensitization 1 68.64 Quite High
Neurotransmitter 7 65.04 Quite High
central sensitization 1 54.48 Quite High
behavioral therapy 1 52.08 Quite High
Acupuncture 1 50.48 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 147 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Depression 36 99.80 Very High Very High Very High
Neuropathic Pain 3 98.06 Very High Very High Very High
Disease 9 92.36 High High
Chronic Disease 1 85.28 High High
Osteoarthritis 3 81.36 Quite High
Fatigue 16 74.40 Quite High
Anxiety Disorder 15 74.36 Quite High
Cognitive Disorder 10 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent research suggests that these conditions are in fact differential symptom presentations of a single underlying condition, and that major depressive disorder (MDD) and FM (as well as neuropathic pain) are both associated with neuroplastic changes in the CNS.13 However, in a recent review of the relationship between FM and MDD, Pae et al assert that currently available findings do not support the assumption that MDD and FM refer to the same underlying construct, nor can they be seen as subsidiaries of one disease concept.14
Localization (relationship) of FM associated with depression, neuropathic pain, central nervous system, disease and fibrositis
1) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 1.79 Pain Relevance 0.71
Additionally, several collagen types such as III, V, VI, IX, X, XI, XII, and XIV, small proteoglycans, such as lumican, biglycan, decorin and fibromodulin, and other glycoproteins, such as fibronectin and amyloid comprise the nucleus [22, 23].
Localization (several) of fibromodulin in nucleus associated with alzheimer's dementia
2) Confidence 0.14 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684219 Disease Relevance 0.17 Pain Relevance 0.03
Additionally, several collagen types such as III, V, VI, IX, X, XI, XII, and XIV, small proteoglycans, such as lumican, biglycan, decorin and fibromodulin, and other glycoproteins, such as fibronectin and amyloid comprise the nucleus [22, 23].
Localization (comprise) of fibromodulin in nucleus associated with alzheimer's dementia
3) Confidence 0.14 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684219 Disease Relevance 0.18 Pain Relevance 0

General Comments

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