INT270346

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.88
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vcsa1)
Anatomy Link Frequency
urethra 8
ureter 2
bladder 2
Vcsa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 1 92.32 High High
Pain 1 91.24 High High
Inflammation 60 62.24 Quite High
Enkephalin 8 36.76 Quite Low
substance P 8 36.00 Quite Low
Spinal cord 9 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 1152 99.96 Very High Very High Very High
Aging 32 99.62 Very High Very High Very High
Diabetes Mellitus 466 99.46 Very High Very High Very High
Stress Incontinence 16 99.16 Very High Very High Very High
Pain 1 91.24 High High
INFLAMMATION 69 62.24 Quite High
Disease 19 61.20 Quite High
Disorders Of The Lacrimal System 1 57.24 Quite High
Endotoxemia 6 51.68 Quite High
Natriuresis 8 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vcsa1 expression is hormonally regulated by androgens [33,36], and the expression of opiorphin family genes may be similarly regulated [37].


Regulation (regulated) of Gene_expression (expression) of Vcsa1
1) Confidence 0.59 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.32 Pain Relevance 0.17
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Neg (no) Regulation (change) of Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
2) Confidence 0.51 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.94 Pain Relevance 0
In an aging rat model for ED, Vcsa1 expression is down-regulated.[22] We have recently shown that treating these rats to restore erectile function using gene therapy (hMaxiK) or tadalifil reverses the down-regulation of Vcsa1.
Regulation (regulation) of Gene_expression (expression) of Vcsa1 associated with reprotox - general 2 and aging
3) Confidence 0.37 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.53 Pain Relevance 0
Overall our paper demonstrated a correlation between decreased expression of Vcsa1 in the corpora and erectile function in at least three models of ED.[22]
Regulation (correlation) of Gene_expression (expression) of Vcsa1 associated with reprotox - general 2
4) Confidence 0.37 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.33 Pain Relevance 0
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Neg (no) Regulation (change) of Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
5) Confidence 0.22 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.95 Pain Relevance 0
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Neg (no) Regulation (change) of in bladder Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
6) Confidence 0.17 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.94 Pain Relevance 0
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Neg (no) Regulation (change) of in ureter Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
7) Confidence 0.17 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.94 Pain Relevance 0
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Neg (no) Regulation (change) of in ureter Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
8) Confidence 0.08 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.95 Pain Relevance 0
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Neg (no) Regulation (change) of in bladder Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
9) Confidence 0.08 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.95 Pain Relevance 0

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