INT270351

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Anatomy Link Frequency
heart 1
Ctsk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 3 56.32 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
substance P 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 1 99.96 Very High Very High Very High
Breast Cancer 1 91.80 High High
Disorder Of Lipid Metabolism 2 82.48 Quite High
Injury 7 80.72 Quite High
Reprotox - General 2 288 72.64 Quite High
Bronchiolitis Obliterans 3 72.48 Quite High
Lung Injury 2 57.60 Quite High
Toxicity 3 57.52 Quite High
Cv Unclassified Under Development 3 56.32 Quite High
Hyperglycemia 6 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cysteine proteases of the cathepsin family were also differentially expressed between control and ligated rats, with cathepsin K being down-regulated most.
Negative_regulation (regulated) of cathepsin K
1) Confidence 0.07 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.55 Pain Relevance 0.03
Cysteine proteases of the cathepsin family were also differentially expressed between control and ligated rats, with cathepsin K being down-regulated most.
Negative_regulation (down) of cathepsin K
2) Confidence 0.07 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.55 Pain Relevance 0.03
For instance, Bruggink showed in patients with end-stage heart failure, cathepsin K protein after Left Ventricular Assist Device (LVAD) decreased in macrophage, while its mRNA levels have been upregulated during LVAD treatment.36 Other research about the role of Peroxiredoxins (Prxs), a recent group of peroxidases with high antioxidant activity in breast cancer revealed low expression of PrxI, II, v and vI proteins in contrast with high levels of mRNA.34 Although cited research has been focused on different tissues and molecules in comparison to our study, these kinds of paradoxical discrepancies between mRNA and protein level of HO-1 may be explained by translational and post translational alterations as mentioned in these studies.34 Conformational alterations of HO-1 protein following unclear mutations after SM exposure could be one of the reasons for this discrepancy.35 Another hypothesis offers destabilizing of HO-1 protein via phosphorylation and over oxidation which culminate in protein degradation35 which might refer to the secondary effect of SM.
Negative_regulation (decreased) of cathepsin K in heart associated with breast cancer and myocardial infarction
3) Confidence 0.06 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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