INT270353

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.87
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Ctsk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 30 53.08 Quite High
ischemia 1 51.36 Quite High
antagonist 30 50.00 Quite Low
Potency 30 41.28 Quite Low
isoflurane 6 19.16 Low Low
agonist 24 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 696 98.96 Very High Very High Very High
Disorder Of Lipid Metabolism 1 84.44 Quite High
Hypercalcemia 84 78.72 Quite High
Reprotox - General 2 144 70.96 Quite High
Toxicity 25 55.84 Quite High
Hyperglycemia 3 53.44 Quite High
Injury 1 52.24 Quite High
Cv Unclassified Under Development 1 51.36 Quite High
Bone Cancer 6 46.20 Quite Low
Multiple Myeloma 36 45.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDM02 inhibits expression of cathepsin K in differentiating OCs (d).
Gene_expression (expression) of cathepsin K
1) Confidence 0.12 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.31 Pain Relevance 0
The strong effects of PDM02, PDM10, and, to a lesser extent, PDM11 on OC differentiation were demonstrated in three different ways: (1) by inhibition of the formation of TRAP-positive multinucleated cells, (2) by inhibition of the release of TRAP in the medium, and (3) by downregulation of the expression of cathepsin K, all widely recognized hallmarks of OC differentiation.
Gene_expression (expression) of cathepsin K
2) Confidence 0.12 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.75 Pain Relevance 0.03
Cathepsin K expressions are representative of at least two independent experiments.
Gene_expression (expressions) of Cathepsin K
3) Confidence 0.12 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.32 Pain Relevance 0
Similarly, the expression of cathepsin K was strongly suppressed in cultures treated with PDM02 in a dose-dependent manner (Fig. 1d).Fig. 1Effect of RSV analogues on RANKL-induced OC differentiation.
Gene_expression (expression) of cathepsin K associated with respiratory syncytial virus
4) Confidence 0.12 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.36 Pain Relevance 0
Supplementation of the culture media with either PDM10 or PDM11 reduced the levels of TRAP activity released into the culture media (Supplementary Fig. 1) and suppressed the expression of cathepsin K in a dose-dependent fashion.
Gene_expression (expression) of cathepsin K
5) Confidence 0.12 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.21 Pain Relevance 0
Cysteine proteases of the cathepsin family were also differentially expressed between control and ligated rats, with cathepsin K being down-regulated most.
Gene_expression (expressed) of cathepsin K
6) Confidence 0.10 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.55 Pain Relevance 0.03
When compared with cultures treated with rhM-CSF alone, rhRANKL induced the formation of numerous TRAP+ multinucleated cells (Fig. 1a, b), increased the levels of TRAP activity in media (Fig. 1c), and strongly induced the expression of cathepsin K (Fig. 1d), all known to be hallmarks of OC differentiation.
Gene_expression (expression) of cathepsin K
7) Confidence 0.09 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.37 Pain Relevance 0

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