INT270427

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.82
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ACHE) extracellular space (ACHE) extracellular region (ACHE)
cell adhesion (ACHE) Golgi apparatus (ACHE) plasma membrane (ACHE)
ACHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 2 81.44 Quite High
Inflammation 9 58.80 Quite High
Clonidine 96 50.00 Quite Low
positron emission tomography 8 22.68 Low Low
Central nervous system 6 16.72 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 7 94.96 High High
Toxicity 9 92.20 High High
Respiratory Failure 10 87.20 High High
Poisoning 40 78.36 Quite High
Death 14 76.60 Quite High
Cognitive Disorder 28 73.68 Quite High
INFLAMMATION 10 58.80 Quite High
Disease 123 50.00 Quite Low
Targeted Disruption 7 42.80 Quite Low
Neurodegenerative Disease 2 41.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oximes, such as pralidoxime, can reactivate acetylcholinesterase but the ability to reverse acetylcholinesterase (AChE) inhibition with oximes varies with the type of pesticide ingested and time to treatment as both these factors affect the rate of enzyme ageing [8,9].
Negative_regulation (reverse) of AChE Neg (inhibition) Binding (inhibition) of associated with aging
1) Confidence 0.42 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 0.77 Pain Relevance 0.04
Oximes, such as pralidoxime, can reactivate acetylcholinesterase but the ability to reverse acetylcholinesterase (AChE) inhibition with oximes varies with the type of pesticide ingested and time to treatment as both these factors affect the rate of enzyme ageing [8,9].
Negative_regulation (reverse) of acetylcholinesterase Neg (inhibition) Binding (inhibition) of associated with aging
2) Confidence 0.42 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 0.77 Pain Relevance 0.04
Lipocrine, a hybrid compound of tacrine and lipoic acid, blocks the catalytic binding site of acetylcholinesterase and ?
Negative_regulation (blocks) of acetylcholinesterase Binding (site) of
3) Confidence 0.05 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

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