INT270447

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.61
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Smo) plasma membrane (Smo) cilium (Smo)
cytoplasm (Smo) signal transducer activity (Smo)
Smo (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 48 96.92 Very High Very High Very High
Inflammation 24 82.40 Quite High
cytokine 32 76.00 Quite High
Peripheral nervous system 10 69.84 Quite High
Demyelination 2 63.44 Quite High
Multiple sclerosis 10 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Sciatic nerve 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5 99.28 Very High Very High Very High
Skin Cancer 1 98.60 Very High Very High Very High
Malignant Neoplastic Disease 2 97.44 Very High Very High Very High
Experimental Autoimmune Neuritis 48 96.92 Very High Very High Very High
Syndrome 38 95.76 Very High Very High Very High
Necrosis 3 84.76 Quite High
INFLAMMATION 26 82.40 Quite High
Injury 7 72.08 Quite High
Autoimmune Disease 14 71.60 Quite High
Immunization 4 69.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of observations support the role of apoE in maintaining the integrity of the BNB or BBB.
BNB Binding (integrity) of
1) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 1.09 Pain Relevance 0.60
Although there still lacks evidence that apoE isoforms contribute differently in maintaining BNB or BBB integrity, considering the preference of apoE isoforms binding to different lipoprotein and apoE receptors, it might be presumed that apoE isoforms might influence the recovery of GBS due to cholesterol transport difference in regeneration and remyelination [134, 135].
BNB Binding (integrity) of associated with syndrome
2) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.88 Pain Relevance 0.15
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Smo Binding (binding) of
3) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.65 Pain Relevance 0.04

General Comments

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