INT270453

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.83
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
cornea 1
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 18 98.74 Very High Very High Very High
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 3 97.22 Very High Very High Very High
Retinal Neovascularization 3 96.78 Very High Very High Very High
Burns 18 96.12 Very High Very High Very High
Corneal Neovascularization 18 93.00 High High
Wound Healing 6 77.40 Quite High
Cancer 9 74.64 Quite High
Injury 21 48.12 Quite Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Bacterial Infection 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Regulation (target) of Shh associated with hypoxia and retinal neovascularization
1) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.27 Pain Relevance 0
Role of exogenous Shh and cyclopamine on development of corneal stromal neovascularization in vivo
Regulation (Role) of Shh
2) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.32 Pain Relevance 0
Shh did not affect the expression levels of angiogenic cytokines in cultured cell types. mRNA and protein expression levels of Shh and Ptc were under the detection limit in an uninjured cornea, but Shh but not Ptc was upregulated in a healing, alkali-burned, vascularized cornea.
Regulation (under) of Shh in cornea associated with cytokine
3) Confidence 0.12 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2684749 Disease Relevance 0.24 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox