INT27049

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.65
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Trhde)
Anatomy Link Frequency
neurons 1
brain 1
Trhde (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 103 97.24 Very High Very High Very High
Inflammation 55 91.00 High High
Enkephalin 2 69.44 Quite High
Neuropeptide 6 63.92 Quite High
substance P 3 62.88 Quite High
Calcitonin gene-related peptide 13 61.60 Quite High
Peripheral nerve injury 17 5.00 Very Low Very Low Very Low
Sciatic nerve 13 5.00 Very Low Very Low Very Low
Spinal cord 9 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 103 97.24 Very High Very High Very High
INFLAMMATION 66 91.00 High High
Nociception 5 65.68 Quite High
Nervous System Injury 31 50.00 Quite Low
Pancreatitis 7 50.00 Quite Low
Pain 11 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Cystitis 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices.
Negative_regulation (inhibition) of Pyroglutamyl peptidase in brain
1) Confidence 0.36 Published 1989 Journal Neuropeptides Section Title Doc Link 2575716 Disease Relevance 0 Pain Relevance 0.06
It weakly inhibited cytosolic pyroglutamyl peptidase I (EC 3.4.19.3).
Negative_regulation (inhibited) of pyroglutamyl peptidase
2) Confidence 0.31 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2575716 Disease Relevance 0 Pain Relevance 0.07
Although the number of PAP-II-positive neurons was decreased to ~15% of total neurons at day 4, PAP-II was still present in many DRG neurons (~16%) at day 7, suggesting a long-lasting up-regulation of this protein.
Negative_regulation (decreased) of PAP-II in neurons associated with dorsal root ganglion
3) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.65 Pain Relevance 0.92

General Comments

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