INT27050

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 14.07
Pain Relevance 8.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Trhde)
Anatomy Link Frequency
neurons 4
nerve 2
spinal 1
sciatic nerve 1
proximal 1
Trhde (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 605 99.88 Very High Very High Very High
dorsal root ganglion 1133 99.72 Very High Very High Very High
Spinal cord 99 99.56 Very High Very High Very High
Dorsal horn 11 98.80 Very High Very High Very High
Peripheral nerve injury 187 98.56 Very High Very High Very High
Sciatic nerve 143 98.16 Very High Very High Very High
Enkephalin 1 93.52 High High
Inflammatory stimuli 11 90.72 High High
Inflammatory response 99 89.40 High High
substance P 33 88.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 726 99.88 Very High Very High Very High
Ganglion Cysts 1133 99.72 Very High Very High Very High
Nervous System Injury 341 98.56 Very High Very High Very High
Nociception 55 94.84 High High
Pain 121 84.12 Quite High
Cystitis 44 76.56 Quite High
Injury 55 74.64 Quite High
Inflammatory Pain 11 67.44 Quite High
Brain Injury 11 52.84 Quite High
Pancreatitis 77 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, accumulated PAP-II was found in the proximal portion of ligated sciatic nerve and dorsal root, suggesting an existence of anterograde transport of this protein to nerve terminals.
Positive_regulation (accumulated) of PAP-II in proximal associated with sciatic nerve
1) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.39 Pain Relevance 0.91
The number of large DRG neurons that co-expressed PAP-II and NPY was markedly increased, contributing to 61.1 ± 2.8% of total PAP-II-containing DRG neurons (Fig. 7A and 7B).
Positive_regulation (increased) of PAP-II in neurons associated with dorsal root ganglion
2) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.29 Pain Relevance 0.79
We next asked whether the increase in PAP-II mRNA resulted in an elevated protein level in small DRG neurons.
Spec (whether) Positive_regulation (increase) of PAP-II in neurons associated with dorsal root ganglion
3) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.59 Pain Relevance 0.75
However, the number of PAP-II-immunoreactive neurons was markedly increased in L4 and L5 DRGs after peripheral inflammation induced by intraplantar CFA injection (Fig. 3A and 3B).
Positive_regulation (increased) of PAP-II in neurons associated with inflammation
4) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.54 Pain Relevance 0.73
Immunostaining showed that only ~2% of DRG neurons were positive for PAP-II in L4 and L5 DRGs on the contralateral side after unilateral axotomy of the sciatic nerve (Fig. 5A and 5B), similar to that found in the DRGs of normal rats.
Positive_regulation (positive) of PAP-II in neurons associated with dorsal root ganglion and sciatic nerve
5) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.62 Pain Relevance 0.92
These results suggest a potential role of PAP-II in the modulation of the activity of spinal sensory circuits in pathological conditions.
Positive_regulation (role) of PAP-II in spinal
6) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.39 Pain Relevance 1.03
Using immunostaining, we found that PAP-II was accumulated in the nerve fibers in the portion of the ligated sciatic nerve and dorsal root that was proximal to L4 and L5 DRGs but not in the distal portion (Fig. 8A and 8B), suggesting that PAP-II can be anterogradely transported to the afferent terminals.
Positive_regulation (accumulated) of PAP-II in nerve associated with sciatic nerve
7) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 0.49 Pain Relevance 0.50
The microarray signal for PAP-I mRNA was increased by 2394%, 1660% and 1128% at day 2, 4 and 7 after CFA injection, respectively, while the signal for PAP-II mRNA was increased by 87% at day 2, 134% at day 4 and 94% at day 7.
Positive_regulation (increased) of PAP-II
8) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.57 Pain Relevance 0.70
After peripheral tissue inflammation, the accumulation of PAP-II in the proximal side of the dorsal root and the sciatic nerve was significantly increased (Fig. 8B and 8C).
Positive_regulation (accumulation) of PAP-II in sciatic nerve associated with inflammation and sciatic nerve
9) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 0.57 Pain Relevance 0.57
However, the expression pattern of PAP-II induced by inflammation is distinct from that induced by nerve injury.
Positive_regulation (induced) of PAP-II in nerve associated with nervous system injury and inflammation
10) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.65 Pain Relevance 0.76
However, the expression level of PAP-II was markedly increased in the DRGs one day after intraplantar CFA injection (Fig. 2A).
Positive_regulation (increased) of PAP-II
11) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 0.96 Pain Relevance 0.48
An even higher recovery was observed in slices from brain regions with relatively high levels of pyroglutamyl peptidase II.
Positive_regulation (levels) of pyroglutamyl peptidase in brain
12) Confidence 0.29 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2575716 Disease Relevance 0 Pain Relevance 0.09

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