INT270573

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus 2
PPP3R2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 22.80 Low Low
cytokine 18 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 40 73.20 Quite High
Helminth Infection 44 60.36 Quite High
Infection 164 50.00 Quite Low
Hypersensitivity 18 23.52 Low Low
INFLAMMATION 6 22.80 Low Low
Schistosomiasis 42 5.00 Very Low Very Low Very Low
Fibrosis 16 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Worm Infection 8 5.00 Very Low Very Low Very Low
Eosinophilia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in the absence of CsA, known to prevent nuclear translocation of NF-AT through inhibition of the calcium-dependent phosphatase calcineurin, calcineurin activates NF-AT by dephosphorylation resulting in NF-AT translocation to the nucleus where it binds to specific DNA sequences that control gene transcription.
Negative_regulation (inhibition) of calcineurin in nucleus
1) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.26 Pain Relevance 0
Therefore, in the absence of CsA, known to prevent nuclear translocation of NF-AT through inhibition of the calcium-dependent phosphatase calcineurin, calcineurin activates NF-AT by dephosphorylation resulting in NF-AT translocation to the nucleus where it binds to specific DNA sequences that control gene transcription.
Negative_regulation (inhibition) of calcineurin in nucleus
2) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.26 Pain Relevance 0

General Comments

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