INT270574

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 5.46
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13RA2) extracellular space (IL13RA2) signal transducer activity (IL13RA2)
Anatomy Link Frequency
GBM 1
eosinophils 1
T cell 1
IL13RA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 72 99.16 Very High Very High Very High
Inflammation 28 96.28 Very High Very High Very High
imagery 208 82.40 Quite High
fibrosis 72 5.00 Very Low Very Low Very Low
addiction 16 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 52 99.88 Very High Very High Very High
Cancer 184 98.96 Very High Very High Very High
Glioma 8 98.68 Very High Very High Very High
Asthma 160 98.38 Very High Very High Very High
Infection 660 98.36 Very High Very High Very High
Helminth Infection 176 98.24 Very High Very High Very High
Eosinophilia 16 97.04 Very High Very High Very High
Hypersensitivity 72 96.64 Very High Very High Very High
INFLAMMATION 28 96.28 Very High Very High Very High
Recurrence 20 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors speculated that the binding of NF-AT to the IL-13 promoter inhibits IL-13 production.
Gene_expression (production) of IL-13
1) Confidence 0.68 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.12 Pain Relevance 0
Thus, binding of YY1 would inhibit the activity of STAT6, which would lead to increased IL-13 expression.
Gene_expression (expression) of IL-13
2) Confidence 0.68 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.23 Pain Relevance 0.04
The presence of this allele correlates with a Ying-Yang 1 factor (YY1) binding site but this site overlaps a STAT6 binding site which seems to inhibit the expression of the IL-13.
Gene_expression (expression) of IL-13
3) Confidence 0.68 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.21 Pain Relevance 0.04
They also confirmed that the rs1800925T/T homozygotes had a greater expression of IL-13, indicating that this in vivo genotype should be associated with susceptibility to allergic inflammation.
Gene_expression (expression) of IL-13 associated with inflammation and hypersensitivity
4) Confidence 0.68 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.32 Pain Relevance 0.05
They also showed that the T/T genotype was associated with a decreased relative inhibition of IL-13 production compared to the C/C (p=0.0016) or the C/T (p=0.0002) genotypes, as well in the patient group and in the control group.
Gene_expression (production) of IL-13
5) Confidence 0.68 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.32 Pain Relevance 0
T cell IL-13 production is usually inhibited by a calcium-inducing signal, which can be reversed by CsA.
Gene_expression (production) of IL-13 in T cell
6) Confidence 0.60 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.36 Pain Relevance 0
As IgE and eosinophils are highly dependent on IL-4, Il-5 and IL-13, it was thought that protection against infection by Schistosoma would involve a Th2 immune response.
Gene_expression (dependent) of IL-13 in eosinophils associated with infection
7) Confidence 0.59 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.29 Pain Relevance 0
As helminthiasis, atopy is the result of aberrant Th2 cytokine response to allergens, with an increased production of IL-4, IL-13, Il-9 and Il-5, with high amounts of allergen-specific and total IgE and eosinophilia.
Gene_expression (production) of IL-13 associated with asthma, helminth infection, eosinophilia and cytokine
8) Confidence 0.53 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2685643 Disease Relevance 1.02 Pain Relevance 0.13
Further analysis of the expression of the IL-13R in samples obtained during this trial will help to answer some of these questions.
Gene_expression (expression) of IL-13R
9) Confidence 0.01 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2996533 Disease Relevance 0.70 Pain Relevance 0.11
A recent study using a commercially available tissue array and IL-13R antibody showed that up to 75% of patients with GBM over-express the IL-13R.
Gene_expression (express) of IL-13R in GBM associated with glioblastoma
10) Confidence 0.01 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2996533 Disease Relevance 0.65 Pain Relevance 0.03
Heterogeneous expression of the IL-13R has been demonstrated in tumor samples as well as variation in the expression from various sites of tumor, however the use of different antibodies used in these studies makes it difficult to assess the real impact of these findings [6, 22–25].
Gene_expression (expression) of IL-13R associated with cancer
11) Confidence 0.01 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2996533 Disease Relevance 0.71 Pain Relevance 0
With respect to target expression, several studies have shown that the target of CB, the IL-13R, is over-expressed in a large number of high grade glioma explants [6, 22].
Gene_expression (expressed) of IL-13R associated with glioma
12) Confidence 0.01 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2996533 Disease Relevance 0.53 Pain Relevance 0.03

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