INT270576

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.01
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13RA2) extracellular space (IL13RA2) signal transducer activity (IL13RA2)
Anatomy Link Frequency
T cell 2
IL13RA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 76.96 Quite High
cytokine 36 5.00 Very Low Very Low Very Low
fibrosis 36 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 80 96.80 Very High Very High Very High
Helminth Infection 88 83.96 Quite High
Hypersensitivity 36 77.68 Quite High
INFLAMMATION 12 76.96 Quite High
Infection 328 50.00 Quite Low
Attention Deficit Hyperactivity Disorder 4 38.48 Quite Low
Schistosomiasis 84 5.00 Very Low Very Low Very Low
Fibrosis 32 5.00 Very Low Very Low Very Low
Disease 28 5.00 Very Low Very Low Very Low
Worm Infection 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of this allele correlates with a Ying-Yang 1 factor (YY1) binding site but this site overlaps a STAT6 binding site which seems to inhibit the expression of the IL-13.
Negative_regulation (inhibit) of Gene_expression (expression) of IL-13
1) Confidence 0.52 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.21 Pain Relevance 0.04
They also showed that the T/T genotype was associated with a decreased relative inhibition of IL-13 production compared to the C/C (p=0.0016) or the C/T (p=0.0002) genotypes, as well in the patient group and in the control group.
Negative_regulation (inhibition) of Gene_expression (production) of IL-13
2) Confidence 0.52 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.33 Pain Relevance 0
T cell IL-13 production is usually inhibited by a calcium-inducing signal, which can be reversed by CsA.
Negative_regulation (inhibited) of Gene_expression (production) of IL-13 in T cell
3) Confidence 0.45 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.36 Pain Relevance 0
The authors speculated that the binding of NF-AT to the IL-13 promoter inhibits IL-13 production.
Negative_regulation (inhibits) of Gene_expression (production) of IL-13
4) Confidence 0.38 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.12 Pain Relevance 0

General Comments

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