INT270625

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) lipid metabolic process (Insig1)
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 78 99.88 Very High Very High Very High
adenocard 1 93.08 High High
chemokine 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 41 99.04 Very High Very High Very High
Autoimmune Disease 15 97.04 Very High Very High Very High
Targeted Disruption 19 93.48 High High
Diabetes Mellitus 190 91.24 High High
Death 3 71.12 Quite High
Obesity 2 63.92 Quite High
Injury 4 48.32 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Diabetes Mellitus-type I 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucose is the major physiologic regulator of insulin gene expression; it coordinately controls the recruitment of transcription factors (e.g., pancreatic/duodenal homeobox-1, mammalian homologue of avian MafA/L-Maf, Beta2/Neuro D), the rate of transcription, and the stability of insulin mRNA [4].
Regulation (regulator) of Gene_expression (expression) of insulin gene
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.28 Pain Relevance 0
BLI is a sensitive method for monitoring insulin gene expression in extrapancreatic tissues in vivo.
Regulation (sensitive) of Gene_expression (expression) of insulin gene associated with imagery
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827564 Disease Relevance 0.50 Pain Relevance 0.16
Aristaless-like homeobox 3 (Alx3) is a candidate for its capability to regulate insulin gene expression in pancreatic ß cells [30].
Regulation (regulate) of Gene_expression (expression) of insulin gene
3) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.62 Pain Relevance 0.05

General Comments

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