INT270628

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp2) mitochondrion (Ucp2)
Anatomy Link Frequency
liver 1
Ucp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5 99.92 Very High Very High Very High
diabetic neuropathy 2 98.80 Very High Very High Very High
tolerance 6 46.04 Quite Low
Inflammatory response 2 17.56 Low Low
cerebral cortex 1 15.36 Low Low
chemokine 7 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 100.00 Very High Very High Very High
INFLAMMATION 7 99.92 Very High Very High Very High
Diabetes Mellitus 155 99.08 Very High Very High Very High
Diabetic Neuropathy 2 98.80 Very High Very High Very High
Hypertrophy 1 83.92 Quite High
Obesity 14 73.92 Quite High
Fatty Liver 1 69.88 Quite High
Genetic Predisposition To Disease 4 54.08 Quite High
Body Weight 16 49.68 Quite Low
Congenital Anomalies 1 19.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammation is stronger in Ucp2-knockout mice and islets, leading to exacerbated diabetic conditions [93].
Regulation (stronger) of Ucp2-knockout associated with targeted disruption, inflammation and diabetes mellitus
1) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.12 Pain Relevance 0.10
In contrast to liver-UCP2, there was no change in BAT-UCP1 mRNA expression in HFD-fed GhrR KO mice (Figure 6B).


Neg (no) Regulation (change) of UCP2 in liver
2) Confidence 0.23 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.22 Pain Relevance 0

General Comments

This test has worked.

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