INT270629

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 25
Disease Relevance 9.71
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vav3) intracellular (Vav3) cytoplasm (Vav3)
Anatomy Link Frequency
eye 6
retina 5
macrophage 2
cornea 2
lens 1
Vav3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 46 63.28 Quite High
adenocard 2 34.68 Quite Low
Inflammation 33 5.00 Very Low Very Low Very Low
chemokine 14 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 1242 99.76 Very High Very High Very High
Diabetes Mellitus 308 99.72 Very High Very High Very High
Hydrophthalmos 115 99.24 Very High Very High Very High
Ocular Hypertension 1311 97.60 Very High Very High Very High
Targeted Disruption 71 97.12 Very High Very High Very High
Ganglion Cysts 92 96.88 Very High Very High Very High
Optic Disorders 46 87.04 High High
Adhesions 25 79.64 Quite High
Disease 62 75.00 Quite High
Blindness 23 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vav3 mRNA was more abundantly expressed than that of Vav2 in the TM and the retina.
Gene_expression (expressed) of Vav3 mRNA in retina
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.38 Pain Relevance 0
Vav1 is expressed specifically in lymphoid lineage cells, whereas Vav2 and Vav3 are more widely expressed [5], [7].
Gene_expression (expressed) of Vav3
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.58 Pain Relevance 0
Expression of Vav2 and Vav3 in Mouse and Human Eyes
Gene_expression (Expression) of Vav3 in Eyes
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.53 Pain Relevance 0
Gene expression levels of both Vav2 and Vav3 in the eye were comparable to levels found in immune cells where Vavs play a critical role [5], [7]–[16].
Gene_expression (expression) of Vav3 in eye
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.31 Pain Relevance 0
The expression of Vav2 and Vav3 tissues was demonstrated in the iridocorneal angle and retina in both mouse and human eyes.
Gene_expression (expression) of Vav3 in eyes
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816215 Disease Relevance 0.96 Pain Relevance 0
We observed Vav2 and Vav3 proteins expression in the tissues of human iridocorneal angle and retina.
Gene_expression (expression) of Vav3 in retina
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.55 Pain Relevance 0
In addition, since the expression of Vav2 and Vav3 was detected in ocular tissues other than those comprising the iridocorneal angle, it will be necessary in future studies to consider how their deficiency in these tissues might have potentially contributed to the spontaneous glaucoma phenotype in any way.
Gene_expression (expression) of Vav3 associated with glaucoma
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.97 Pain Relevance 0
Quantitative real-time PCR revealed that Vav2 and Vav3 mRNA are expressed in TM, cornea, retina, lens, iris, and ciliary body in the mouse eye (Figure 5A).
Gene_expression (expressed) of Vav3 mRNA in iris
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.41 Pain Relevance 0
Briefly, to detect mRNAs for Vav2 and Vav3, specific antisense oligonucleotide probes were synthesizedas follows:(2275–2319;45mers)5?
Gene_expression (detect) of Vav3
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0 Pain Relevance 0.06
Several other genes are not listed as candidate genes in Table 1 because of their negative evidence in T1D; these genes include pancreatic amylase (Amy2), vav3 oncogene (Vav3), and macrophage colony-stimulating factor 1 (Csf1).
Gene_expression (include) of Vav3 in macrophage associated with diabetes mellitus
10) Confidence 0.62 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.77 Pain Relevance 0
Several other genes are not listed as candidate genes in Table 1 because of their negative evidence in T1D; these genes include pancreatic amylase (Amy2), vav3 oncogene (Vav3), and macrophage colony-stimulating factor 1 (Csf1).
Gene_expression (include) of vav3 oncogene in macrophage associated with diabetes mellitus
11) Confidence 0.62 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.77 Pain Relevance 0
In order to understand the pathogenesis of the Vav2/Vav3-deficient eye phenotype, we examined the mRNA and protein expression patterns of Vav2 and Vav3 in the eye (Figure 5).
Spec (examined) Gene_expression (expression) of Vav3 in eye
12) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.43 Pain Relevance 0
Both Vav2 and Vav3 proteins were also expressed in human retina and iridocorneal angle.
Gene_expression (expressed) of Vav3 in retina
13) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.12 Pain Relevance 0
Loss of Vav2 and Vav3 expression is associated with changes in the iridocorneal angle, with eventual chronic angle closure.
Gene_expression (expression) of Vav3
14) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.77 Pain Relevance 0
Gene expression levels of both Vav2 and Vav3 in the eye were comparable to levels found in immune cells where Vavs play a critical role [5], [7]–[16].
Gene_expression (levels) of Vav3 in eye
15) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.31 Pain Relevance 0
Also, we assessed Vav2 and Vav3 protein expression by immunoblotting in both mouse and human eyes (Figure 5C).
Gene_expression (expression) of Vav3 in eyes
16) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0 Pain Relevance 0
In mouse eyes, expression of both Vav2 and Vav3 was demonstrated in several ocular tissues including the iridocorneal angle, retina, cornea, and sclera.
Gene_expression (expression) of Vav3 in cornea
17) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.05 Pain Relevance 0
The co- localization of Vav2 and Vav3 mRNA expression in iridocorneal angle, such as TM, was confirmed by ISH.
Gene_expression (expression) of Vav3 mRNA
18) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.05 Pain Relevance 0
Probes of mVav2 and mVav3 were TaqMan probes (Vav2: Mm00437287_m1, Vav3: Mm00445082_m1) purchased from Applied Biosystems (Foster city, CA).
Gene_expression (probes) of Vav3
19) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0 Pain Relevance 0
Quantitative real-time PCR revealed that Vav2 and Vav3 mRNA are expressed in TM, cornea, retina, lens, iris, and ciliary body in the mouse eye (Figure 5A).
Gene_expression (expressed) of Vav3 mRNA in retina
20) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.41 Pain Relevance 0

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