INT270631

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.19
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) lipid metabolic process (Insig1)
Anatomy Link Frequency
liver 6
spleen 1
thymus 1
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 507 99.24 Very High Very High Very High
adenocard 1 92.72 High High
agonist 31 80.20 Quite High
Inflammatory response 4 46.56 Quite Low
Inflammation 19 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 118 99.88 Very High Very High Very High
Diabetes Mellitus 389 99.72 Very High Very High Very High
Hyperglycemia 239 99.32 Very High Very High Very High
Autoimmune Disease 15 97.04 Very High Very High Very High
Hepatocellular Cancer 2 95.08 Very High Very High Very High
Injury 27 83.84 Quite High
Death 3 70.76 Quite High
Obesity 27 63.92 Quite High
Disease 21 51.08 Quite High
INFLAMMATION 23 46.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spleen is one of the organs that demonstrated positive insulin gene expression under diabetic conditions [5].
Gene_expression (expression) of insulin gene in spleen associated with diabetes mellitus
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.33 Pain Relevance 0.17
A highly conserved region approximately 400 bp immediately upstream of the transcription initiation start site confers both tissue-specific expression and metabolic regulation of the insulin gene [3].
Gene_expression (expression) of insulin gene
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.12 Pain Relevance 0
In conclusion, BLI is a valid, sensitive, and semi-quantitative technology for monitoring insulin gene expression when used in combination with transgenic mice expressing reporter gene luciferase under the regulation of the insulin gene promoter.
Gene_expression (expression) of insulin gene associated with targeted disruption and imagery
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.24 Pain Relevance 0.09
Glucose is the major physiologic regulator of insulin gene expression; it coordinately controls the recruitment of transcription factors (e.g., pancreatic/duodenal homeobox-1, mammalian homologue of avian MafA/L-Maf, Beta2/Neuro D), the rate of transcription, and the stability of insulin mRNA [4].
Gene_expression (expression) of insulin gene
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.28 Pain Relevance 0
Rather, it suggests that the level of insulin gene expression in these other tissues may be, if present, lower than that in the liver and beyond the detection limit of the imaging modality.
Gene_expression (expression) of insulin gene in liver associated with imagery
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.22 Pain Relevance 0.12
The novelty of our investigation lies in the application of BLI to the model in which the transgenic mice expressing the reporter gene coding for the firefly-luciferase driven by a rat insulin gene promoter were treated with STZ to induce hyperglycemia, a condition known to induce the insulin gene expression in liver cells.
Gene_expression (expression) of insulin gene in liver associated with hyperglycemia, targeted disruption and imagery
6) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.25 Pain Relevance 0.20
The insulin I gene is expressed in pancreatic beta cells and scattered cells in the thymus [16].
Gene_expression (expressed) of insulin I gene in thymus
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.61 Pain Relevance 0.12
BLI is a sensitive method for monitoring insulin gene expression in extrapancreatic tissues in vivo.
Gene_expression (expression) of insulin gene associated with imagery
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827564 Disease Relevance 0.50 Pain Relevance 0.16
To confirm that the transgene expression mimics that of the endogenous insulin gene, insulin gene expression in the liver was examined by semiquantitative Reverse Transcription (RT)-PCR analyses in autopsy liver samples.


Gene_expression (expression) of insulin gene in liver
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.42 Pain Relevance 0.09
In this study, we aim to establish an animal model to monitor insulin gene expression in extrapanceatic tissues in vivo and characterize the time-course of the insulin promoter activation in liver induced by hyperglycemia through bioluminescence imaging (BLI) [13], [14].
Gene_expression (expression) of insulin gene in liver associated with hyperglycemia and imagery
10) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.69 Pain Relevance 0.09
The insulin gene is normally expressed in pancreatic ?
Gene_expression (expressed) of insulin gene
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0 Pain Relevance 0
The novelty of our investigation lies in the application of BLI to the model in which the transgenic mice expressing the reporter gene coding for the firefly-luciferase driven by a rat insulin gene promoter were treated with STZ to induce hyperglycemia, a condition known to induce the insulin gene expression in liver cells.
Gene_expression (expressing) of insulin gene in liver associated with hyperglycemia, targeted disruption and imagery
12) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.36 Pain Relevance 0.17
activation reduced expression of lipogenic genes, including Fasn, Gpam, and SREBP1c, while Insig1 expression was increased by PPAR?
Gene_expression (expression) of Insig1
13) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.15 Pain Relevance 0.07
To confirm that the transgene expression mimics that of the endogenous insulin gene, insulin gene expression in the liver was examined by semiquantitative Reverse Transcription (RT)-PCR analyses in autopsy liver samples.


Gene_expression (expression) of insulin gene in liver
14) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.42 Pain Relevance 0.09
Aristaless-like homeobox 3 (Alx3) is a candidate for its capability to regulate insulin gene expression in pancreatic ß cells [30].
Gene_expression (expression) of insulin gene
15) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.62 Pain Relevance 0.05

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