INT270649

Context Info Confidence 0.35 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.05 Pain Relevance 0.22

cell adhesion (CCR8) plasma membrane (CCR8) signal transducer activity (CCR8)

Anatomy Link Frequency macrophage 1 CCR8 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 7 95.88 Inflammatory response 2 73.92 Glutamate 2 22.40 Crohn's disease 1 13.80 member 8 1 6.24 Inflammation 5 5.00 diabetic neuropathy 2 5.00 adenocard 1 5.00 agonist 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 154 99.20 Disease 8 96.48 Disease Progression 1 76.08 INFLAMMATION 7 73.92 Diabetes Mellitus-type I 7 39.36 Systemic Lupus Erythematosus 2 25.12 Autoimmune Disease 15 22.08 Hypoglycemia 1 19.36 Renal Disease 5 5.00 Hyperglycemia 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CCR8/CCL1 interaction may play a role in T1D through macrophage recruitment and activation [110].

CCR8 Binding (interaction) of in macrophage associated with diabetes mellitus

1) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.05 Pain Relevance 0.22

General Comments

This test has worked.