INT27067

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Context Info
Confidence 0.18
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.46
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh, Avp) extracellular region (Crh, Avp) response to stress (Crh, Avp)
signal transduction (Avp) signal transducer activity (Avp) cytoplasm (Crh)
Anatomy Link Frequency
pituitary 2
lobes 2
Crh (Rattus norvegicus)
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2 100.00 Very High Very High Very High
Kinase C 3 94.28 High High
Cholecystokinin 5 88.72 High High
Dynorphin 3 80.24 Quite High
narcan 1 74.80 Quite High
opiate 1 71.56 Quite High
antagonist 39 62.80 Quite High
Action potential 1 24.48 Low Low
Potency 1 7.84 Low Low
agonist 22 7.16 Low Low
Disease Link Frequency Relevance Heat
Stress 49 95.64 Very High Very High Very High
Urological Neuroanatomy 1 87.28 High High
Targeted Disruption 22 83.96 Quite High
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRH stimulates the secretion of oxytocin and vasopressin from combined neurointermediate lobes but not from isolated neural lobes.
CRH Positive_regulation (stimulates) of Localization (secretion) of vasopressin in lobes
1) Confidence 0.18 Published 1989 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2575930 Disease Relevance 0 Pain Relevance 0.48
AVP is secreted by cultured pituitary cells but this is not augmented by CRH (569) and remains elevated during exposure to glucocorticoids, which is consistent with its role in chronic stress situations.
CRH Neg (not) Positive_regulation (augmented) of Localization (secreted) of AVP in pituitary associated with stress
2) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.37 Pain Relevance 0.03
In dogs, the release of opioid peptides and vasopressin induced by CRF may contribute in part to mediating the gastric response.
CRF Positive_regulation (induced) of Localization (release) of vasopressin associated with opioid
3) Confidence 0.01 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 3917941 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

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