INT270701

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.12
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Gad2) Golgi apparatus (Gad2) plasma membrane (Gad2)
cytoplasm (Gad2)
Anatomy Link Frequency
dendrites 1
neurons 1
stellate cell 1
synaptic vesicles 1
interneurons 1
Gad2 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 122 99.84 Very High Very High Very High
Pyramidal cell 36 99.70 Very High Very High Very High
gABA 25 68.00 Quite High
Action potential 1 59.28 Quite High
tetrodotoxin 1 21.52 Low Low
interneuron 10 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 48 62.56 Quite High
General Immunology 6 55.76 Quite High
Targeted Disruption 70 16.88 Low Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Body Weight 12 5.00 Very Low Very Low Very Low
Frailty 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Throughout development, basket interneurons extend their axonal branches and form synapses all around the soma of the postsynaptic pyramidal cell, which can be visualized as GAD65-positive puncta rings [6, 7].
Localization (visualized) of GAD65 in interneurons associated with pyramidal cell
1) Confidence 0.74 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.15
It is thus conceivable that the absence of CHL1 in stellate cell axons may impair GABAergic vesicle endocytosis and GAD65 synaptic localization.
Localization (localization) of GAD65 in stellate cell associated with gabaergic
2) Confidence 0.68 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.06 Pain Relevance 0.13
Whereas double labeling and confocal microscopy detected a reduced localization of GAD65 to stellate boutons, ultrastructural analysis confirmed a significant reduction of stellate synapses along Purkinje dendrites.
Localization (localization) of GAD65 in dendrites
3) Confidence 0.68 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.07
m, and then reanalyzed GAD65 and GFAP colocalization (since BG fibers were arranged vertically with an average gap of approximately 5 ?
Localization (colocalization) of GAD65
4) Confidence 0.63 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.10
GAD65, an isoform of glutamic acid decarboxylase, is localized to GABAergic presynaptic terminals and physically coupled to synaptic vesicles ([29]).
Localization (localized) of GAD65 in synaptic vesicles associated with gabaergic
5) Confidence 0.63 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.14
At P16, shortly after stellate neurons begin to send their axons and made synaptic contacts, double labeling revealed a 52% colocalization between GAD65 and GFAP (Figure 3A).
Localization (colocalization) of GAD65 in neurons
6) Confidence 0.63 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.13
Paired comparisons of GAD65 density and colocalization with GFAP used the Wilcoxon signed rank test.
Localization (colocalization) of GAD65 density
7) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.06 Pain Relevance 0

General Comments

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