INT270722

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RPS6KB1) aging (RPS6KB1) ribosome (RPS6KB1)
cytoplasm (RPS6KB1) cytosol (RPS6KB1) signal transduction (RPS6KB1)
RPS6KB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 85.40 High High
rheumatoid arthritis 1 71.60 Quite High
Bile 1 64.84 Quite High
imagery 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 97.64 Very High Very High Very High
INFLAMMATION 5 85.40 High High
Osteoporotic Fractures 1 78.40 Quite High
Systemic Sclerosis 1 75.36 Quite High
Carcinoma 8 74.16 Quite High
Renal Cell Carcinoma 58 73.00 Quite High
Rheumatoid Arthritis 1 71.60 Quite High
Disease 27 66.40 Quite High
Cancer 41 65.04 Quite High
Cardiovascular Disease 21 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of S6K1 itself is also tightly regulated by hierarchical phosphorylation events, which are dependent on the activation of various signal transduction pathways and culminate in the phosphorylation of the rapamycin-sensitive site Thr389.32,33 Hence, reductions in S6 phosphorylation by everolimus is expected to parallel S6K1 inactivation.
Regulation (regulated) of Positive_regulation (Activation) of S6K1
1) Confidence 0.49 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.12 Pain Relevance 0
-untranslated regions and encoding proteins involved in G1- to S-phase progression.30 Mitogen-induced activation of the S6K1 is dependent on mTOR function and has been implicated in the translational regulation of mRNAs possessing a 5?
Regulation (dependent) of Positive_regulation (activation) of S6K1
2) Confidence 0.36 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.15 Pain Relevance 0
This includes an increase of eNOS activity via heat-shock protein 90 (HSP 90), which increases nitric oxide production, protein synthesis and cell proliferation via mammalian target of rapamycin (mTOR) pathway and activation of S6K.
Regulation (target) of Positive_regulation (activation) of S6K associated with shock
3) Confidence 0.17 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.81 Pain Relevance 0.19

General Comments

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