INT270723

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMGCR, LDLR) transport (LDLR) oxidoreductase activity (HMGCR)
endoplasmic reticulum (HMGCR) plasma membrane (LDLR) peroxisome (HMGCR)
Anatomy Link Frequency
liver 2
HMGCR (Homo sapiens)
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 2 68.64 Quite High
Angina 3 55.36 Quite High
Inflammatory marker 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 13 91.72 High High
Cv General 3 Under Development 3 55.36 Quite High
Hypertension 34 53.48 Quite High
Cardiovascular Disease 5 42.84 Quite Low
Dyslipidemia /

Combined Dyslipidemia

19 5.00 Very Low Very Low Very Low
Myocardial Infarction 19 5.00 Very Low Very Low Very Low
Coronary Artery Disease 18 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of HMG-CoA reductase leads to upregulation of low-density lipoprotein cholesterol (LDL-C) receptors in the liver, mediated by activation of sterol regulatory element-binding proteins resulting in enhanced clearance of LDL from the circulation and thus has an important role in preventing atherosclerosis.
Negative_regulation (Inhibition) of HMG-CoA reductase in liver Positive_regulation (upregulation) of low-density lipoprotein cholesterol associated with atherosclerosis
1) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686256 Disease Relevance 0.52 Pain Relevance 0.12

General Comments

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