INT270746

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS, LEP) extracellular region (INS, LEP) small molecule metabolic process (INS)
carbohydrate metabolic process (INS) lipid metabolic process (LEP) cell-cell signaling (INS)
Anatomy Link Frequency
brain 1
INS (Homo sapiens)
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 97.68 Very High Very High Very High
Dopamine 1 66.68 Quite High
Serotonin 2 62.36 Quite High
depression 4 23.40 Low Low
antagonist 2 19.28 Low Low
Cannabinoid receptor 1 18.84 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
antiarrhythmic agent 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 64 95.76 Very High Very High Very High
Overweight 20 78.00 Quite High
Obesity 101 76.88 Quite High
Body Weight 35 57.68 Quite High
Eating Disorder 8 46.44 Quite Low
Left Ventricular Hypertrophy 6 45.52 Quite Low
Sleep Apnea Syndromes 2 44.32 Quite Low
Polycystic Ovary Syndrome 8 43.44 Quite Low
Depression 4 23.40 Low Low
Suicidal Behaviour 1 22.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides increased sympathetic activity, sibutramine treatment in animals and in humans may alter central neuropeptide Y (NPY), and proopiomelanocortin (POMC) mRNA levels and, additionally, the potent anorexigenic hormones leptin and insulin.23,24 Concerning the effects on leptin, it was reported that sibutramine might maintain or even increase leptin transport into the brain during weight loss, while this did not occur during orlistat treatment.25

Studies assessing the weight-lowering potential of sibutramine

insulin Regulation (effects) of leptin in brain associated with weight loss and neuropeptide
1) Confidence 0.07 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686261 Disease Relevance 0.72 Pain Relevance 0.11

General Comments

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