INT270763

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.13 Pain Relevance 0.66

cytosol (IL1B, IKBKB) aging (IL1B) cytoplasm (IKBKB) cell-cell signaling (IL1B) extracellular space (IL1B) signal transduction (IL1B)

IL1B (Homo sapiens) IKBKB (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 99.68 Pain 76 94.40 Osteoarthritis 106 91.16 Inflammatory marker 2 88.24 Arthritis 10 18.24 Paracetamol 16 5.00 cINOD 12 5.00 withdrawal 4 5.00 Pain score 4 5.00 Analgesic 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 99.68 Pain 78 94.40 Osteoarthritis 112 91.16 Arthritis 10 18.24 Disease 36 5.00 Pressure And Volume Under Development 8 5.00 Obesity 6 5.00 Aging 4 5.00 Vomiting 4 5.00 Toxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

More recently, however, it has been demonstrated in animal models that glucosamine has an anti-inflammatory effect via the reduction of nuclear factor kappa beta induced by interleukin-1 (IL-1) (Gouze et al 2002, 2006).

interleukin-1 Negative_regulation (reduction) of nuclear factor kappa beta associated with inflammation

1) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686334 Disease Relevance 0.56 Pain Relevance 0.33

More recently, however, it has been demonstrated in animal models that glucosamine has an anti-inflammatory effect via the reduction of nuclear factor kappa beta induced by interleukin-1 (IL-1) (Gouze et al 2002, 2006).

IL-1 Negative_regulation (reduction) of nuclear factor kappa beta associated with inflammation

2) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686334 Disease Relevance 0.57 Pain Relevance 0.33

General Comments

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