INT270770

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMD) extracellular space (PTH) extracellular region (PTH)
cytoskeleton (DMD) nucleus (DMD) cell-cell signaling (PTH)
Anatomy Link Frequency
hip 1
spine 1
DMD (Homo sapiens)
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 9 82.64 Quite High
Osteoporosis 99 76.76 Quite High
Hypercalcemia 15 5.00 Very Low Very Low Very Low
Frailty 15 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low
Kidney Stones 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together these studies demonstrate that with the bisphosphonate alendronate, combination with PTH results in increased bone turnover and BMD at the spine, but the increases are less than with PTH alone.
BMD Binding (combination) of PTH in spine
1) Confidence 0.10 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.08 Pain Relevance 0
BMD falls off following discontinuation of PTH, and this decrease can be abrogated by alendronate therapy.
BMD Binding (discontinuation) of PTH
2) Confidence 0.10 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0 Pain Relevance 0
Looking specifically at the second year of the study, PTH-AL gained BMD at the spine (4.9%) and the hip (3.6%) compared with the PTH-control group where there was loss of BMD at the spine (?
BMD Binding (gained) of PTH-AL in hip
3) Confidence 0.09 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.08 Pain Relevance 0

General Comments

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