INT270788

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 4
Total Number 16
Disease Relevance 7.54
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AMH) extracellular space (AMH) aging (AMH)
extracellular region (AMH) cell-cell signaling (AMH) cytoplasm (AMH)
Anatomy Link Frequency
ovary 1
AMH (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 13 99.58 Very High Very High Very High
Pain 4 64.52 Quite High
imagery 20 5.00 Very Low Very Low Very Low
endometriosis 13 5.00 Very Low Very Low Very Low
pain pelvic 13 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 754 100.00 Very High Very High Very High
Insulin Resistance 91 98.94 Very High Very High Very High
Hyperandrogenism 39 65.76 Quite High
Pain 4 64.52 Quite High
Hyperinsulinism 13 56.04 Quite High
Calcification 5 7.28 Low Low
Stress 66 5.00 Very Low Very Low Very Low
Adhesions 46 5.00 Very Low Very Low Very Low
Reprotox - General 3 39 5.00 Very Low Very Low Very Low
Osteoporosis 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in AMH levels in antral follicular fluid during metformin treatment could be involved in the local mechanisms mediating the ovulatory restoration.
Regulation (Changes) of AMH
1) Confidence 0.54 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.55 Pain Relevance 0
The current study, confirming and extending our previous data [31], suggests that metformin acts on ovarian AMH levels with additive and direct mechanism of action.
Regulation (acts) of AMH
2) Confidence 0.54 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.37 Pain Relevance 0.05
In fact, significant changes in serum AMH levels in PCOS patients ovulating under metformin, such as in those remaining anovulatory despite treatment were detected.
Regulation (changes) of serum AMH associated with polycystic ovary syndrome
3) Confidence 0.54 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.54 Pain Relevance 0
The present experimental study firstly evaluated the effect of metformin administration on AMH concentrations assayed both on serum and follicular fluid in women affected by PCOS.
Regulation (effect) of AMH associated with polycystic ovary syndrome
4) Confidence 0.39 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.52 Pain Relevance 0
No data regarding metformin effects on follicular fluid anti-Müllerian hormone (AMH) levels were to date available in literature.
Regulation (effects) of anti-M llerian hormone
5) Confidence 0.27 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2912910 Disease Relevance 0.58 Pain Relevance 0
No data regarding metformin effects on follicular fluid anti-Müllerian hormone (AMH) levels were to date available in literature.
Regulation (effects) of AMH
6) Confidence 0.27 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2912910 Disease Relevance 0.58 Pain Relevance 0
In a prospective study [20], metformin acutely improved insulin resistance indexes and restored ovarian morphology, whereas no effect of the metformin-induced improved insulin-sensitivity and AMH levels was observed.
Neg (no) Regulation (effect) of AMH associated with insulin resistance
7) Confidence 0.27 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.49 Pain Relevance 0
The aim of the present study was to evaluate in patients with polycystic ovary syndrome (PCOS) whether metformin administration affects serum and follicular AMH levels, and whether this is related to ovarian response to the treatment.


Spec (whether) Regulation (affects) of AMH in ovary associated with polycystic ovary syndrome
8) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2912910 Disease Relevance 0.66 Pain Relevance 0
Moreover, the same authors showed that 6 months of androgen suppression by either metformin or low-dose dexamethasone treatment failed to influence circulating AMH levels [21].
Neg (failed) Regulation (influence) of AMH associated with dexamethasone
9) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.39 Pain Relevance 0.05
At the moment, the few studies aimed to assess the effects of metformin administration in PCOS patients on serum AMH levels reported controversial findings [9,20-22], and any data is actually available in literature regarding the metformin effects on follicular fluid AMH levels.
Regulation (effects) of serum AMH associated with polycystic ovary syndrome
10) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.81 Pain Relevance 0
Changes in AMH levels in antral follicular fluid during metformin treatment could be involved in the local mechanisms mediating the ovulatory restoration.



Regulation (Changes) of AMH
11) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2912910 Disease Relevance 0.66 Pain Relevance 0
Based on these considerations, the aim of the present study was to evaluate in patients with PCOS whether metformin administration affects serum and follicular AMH levels, and whether this effect is related to ovarian response to the treatment.


Spec (whether) Regulation (affects) of AMH associated with polycystic ovary syndrome
12) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.59 Pain Relevance 0
On the other hand, a slight effect on follicular AMH level was also observed in unresponsive PCOS patients, in fact significant difference in AMH levels was observed between anovulatory PCOS women who had received metformin and untreated anovulatory PCOS patients.
Regulation (effect) of AMH associated with polycystic ovary syndrome
13) Confidence 0.24 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.72 Pain Relevance 0.03
Although information on haptic feedback regarding MIS and especially MIS VR training is rare throughout the literature, study results are indicative toward a positive consensus on the benefits of adding haptic feedback to MIS (-trainers).
Regulation (regarding) of MIS
14) Confidence 0.19 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0
Although information on haptic feedback regarding MIS and especially MIS VR training is rare throughout the literature, study results are indicative toward a positive consensus on the benefits of adding haptic feedback to MIS (-trainers).
Regulation (regarding) of MIS
15) Confidence 0.19 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0
Using a precise, controlled, minimally invasive surgical (MIS) technique, the mini dental implants (MDI) are placed into the jawbone.
Regulation (controlled) of MIS
16) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2871132 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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