INT270801

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Panx1) endoplasmic reticulum (Panx1) plasma membrane (Panx1)
protein complex (Panx1) cell-cell signaling (Panx1)
Anatomy Link Frequency
macrophage 2
Panx1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 8 59.80 Quite High
Inflammation 40 48.80 Quite Low
cytokine 36 47.76 Quite Low
Inflammatory stimuli 8 34.64 Quite Low
antagonist 12 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 48.80 Quite Low
Apoptosis 4 39.04 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and maitotoxin evokes only a panx1-independent slow onset of dye uptake, but in both cases, panx1 inhibition prevents IL-1?
panx1 Binding (evokes) of
1) Confidence 0.33 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
Because P2X7R-induced panx1-dependent dye uptake is calcium-independent, CBX-sensitive, and associated with IL-1?
panx1-dependent Binding (associated) of
2) Confidence 0.33 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
This result implies that panx1 signals downstream to K+ efflux and that K+ efflux is independent of panx1-mediated macrophage permeabilization and dye uptake.
panx1 Binding (independent) of in macrophage
3) Confidence 0.33 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0
There are currently no studies showing high-resolution subcellular localization of endogenous panx1 in macrophage using antibodies that are highly specific for panx1. (5) Can endogenous panx1-like currents be recorded from macrophage?
panx1 Binding (specific) of in macrophage
4) Confidence 0.29 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

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